skip to main content
Idioma:

Anti-Inflammatory Effect of Caffeine on Muscle under Lipopolysaccharide-Induced Inflammation

Eichwald, Tuany ; Solano, Alexandre Francisco ; Souza, Jennyffer ; de Miranda, Taís Browne ; Carvalho, Liebert Bernardes ; Dos Santos Sanna, Paula Lemes ; da Silva, Rodrigo A Foganholi ; Latini, Alexandra

Antioxidants, 2023-02, Vol.12 (3), p.554 [Periódico revisado por pares]

Switzerland: MDPI AG

Texto completo disponível

Citações Citado por
  • Título:
    Anti-Inflammatory Effect of Caffeine on Muscle under Lipopolysaccharide-Induced Inflammation
  • Autor: Eichwald, Tuany ; Solano, Alexandre Francisco ; Souza, Jennyffer ; de Miranda, Taís Browne ; Carvalho, Liebert Bernardes ; Dos Santos Sanna, Paula Lemes ; da Silva, Rodrigo A Foganholi ; Latini, Alexandra
  • Assuntos: adenosine receptors ; Animals ; bioenergetics ; Caffeine ; Cytokines ; DNA methylation ; Epigenetics ; Exercise ; Gene expression ; Health aspects ; inflammasome ; Inflammasomes ; Inflammation ; Interleukin 10 ; Interleukin 13 ; Lipopolysaccharides ; Oxidative metabolism
  • É parte de: Antioxidants, 2023-02, Vol.12 (3), p.554
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    These authors contributed equally to this work.
  • Descrição: Evidence has shown that caffeine administration reduces pro-inflammatory biomarkers, delaying fatigue and improving endurance performance. This study examined the effects of caffeine administration on the expression of inflammatory-, adenosine receptor- (the targets of caffeine), epigenetic-, and oxidative metabolism-linked genes in the muscle of mice submitted to lipopolysaccharide (LPS)-induced inflammation. We showed that caffeine pre-treatment before LPS administration reduced the expression of , , and , and increased and . The negative modulation of the inflammatory response induced by caffeine involved the reduction of inflammasome components, and , promoting an anti-inflammatory scenario. Caffeine treatment promoted the upregulation of adenosinergic receptors, and , an effect that was counterbalanced by LPS. Moreover, there was observed a marked promoter hypermethylation, which could represent a compensatory response towards the increased expression. Though caffeine administration did not alter DNA methylation patterns, the expression of DNA demethylating enzymes, and , was increased in mice receiving Caffeine+LPS, when compared with the basal condition. Finally, caffeine administration attenuated the LPS-induced catabolic state, by rescuing basal levels of expression. Altogether, the anti-inflammatory effects of caffeine in the muscle can be mediated by modifications on the epigenetic landscape.
  • Editor: Switzerland: MDPI AG
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  5 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.