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Hexane extract from Spondias tuberosa (Anacardiaceae) leaves has antioxidant activity and is an anti-Candida agent by causing mitochondrial and lysosomal damages

da Costa Cordeiro, Bruna Maria Pereira ; de Lima Santos, Nataly Diniz ; Ferreira, Magda Rhayanny Assunção ; de Araújo, Larissa Cardoso Corrêa ; Junior, Alexsander Rodrigues Carvalho ; da Conceição Santos, Alan Diego ; de Oliveira, Ana Paula ; da Silva, Alexandre Gomes ; da Silva Falcão, Emerson Peter ; Dos Santos Correia, Maria Tereza ; da Silva Almeida, Jackson Roberto Guedes ; da Silva, Luís Cláudio Nascimento ; Soares, Luiz Alberto Lira ; Napoleão, Thiago Henrique ; da Silva, Márcia Vanusa ; Paiva, Patrícia Maria Guedes

BMC complementary and alternative medicine, 2018-10, Vol.18 (1), p.284-284, Article 284

England: BioMed Central Ltd

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Hexane extract from Spondias tuberosa (Anacardiaceae) leaves has antioxidant activity and is an anti-Candida agent by causing mitochondrial and lysosomal damages
Autor: da Costa Cordeiro, Bruna Maria Pereira ; de Lima Santos, Nataly Diniz ; Ferreira, Magda Rhayanny Assunção ; de Araújo, Larissa Cardoso Corrêa ; Junior, Alexsander Rodrigues Carvalho ; da Conceição Santos, Alan Diego ; de Oliveira, Ana Paula ; da Silva, Alexandre Gomes ; da Silva Falcão, Emerson Peter ; Dos Santos Correia, Maria Tereza ; da Silva Almeida, Jackson Roberto Guedes ; da Silva, Luís Cláudio Nascimento ; Soares, Luiz Alberto Lira ; Napoleão, Thiago Henrique ; da Silva, Márcia Vanusa ; Paiva, Patrícia Maria Guedes
Assuntos: Anacardiaceae ; Anacardiaceae - chemistry ; Analysis ; Antifungal activity ; Antifungal Agents - pharmacology ; Antioxidants ; Antioxidants (Nutrients) ; Antioxidants - pharmacology ; Candida - cytology ; Candida - drug effects ; Chemical properties ; Fatty acids ; Gallic acid ; Hexane ; Hexanes ; Hyperoside ; Lysosomes - drug effects ; Mitochondrial Membranes - drug effects ; Physiological aspects ; Plant Extracts - pharmacology ; Spondias tuberosa
É parte de: BMC complementary and alternative medicine, 2018-10, Vol.18 (1), p.284-284, Article 284
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Spondias tuberosa is a plant that produces a fruit crop with high economic relevance at Brazilian Caatinga. Its roots and leaves are used in folk medicine. Chemical composition of a hexane extract from S. tuberosa leaves was evaluated by thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC) and H nuclear magnetic resonance (NMR). Antioxidant potential was investigated by DPPH and ABTS assays. Antifungal action on Candida species was evaluated determining the minimal inhibitory concentration (MIC ) and putative mechanisms were determined by flow cytometry analysis. In addition, hemolytic activity on human erythrocytes was assessed and the concentration required to promote 50% hemolysis (EC ) was determined. Phytochemical analysis by TLC showed the presence of flavonoids, hydrolysable tannins, saponins and terpenes. The HPLC profile of the extract suggested the presence of gallic acid (0.28 ± 0.01 g%) and hyperoside (1.27 ± 0.01 g%). The representative H NMR spectrum showed saturated and unsaturated fatty acids among the main components. The extract showed weak and moderate antioxidant activity in DPPH (IC : 234.00 μg/mL) and ABTS (IC : 123.33 μg/mL) assays, respectively. It was able to inhibit the growth of C. albicans and C. glabrata with MIC of 2.0 and 0.078 mg/mL, respectively. The treatment of C. glabrata cells with the extract increased levels of mitochondrial superoxide anion, caused hyperpolarization of mitochondrial membrane, and compromised the lysosomal membrane. Weak hemolytic activity (EC : 740.8 μg/mL) was detected. The results demonstrate the pharmacological potential of the extract as antioxidant and antifungal agent, aggregating biotechnological value to this plant and stimulating its conservation.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Hexane extract from Spondias tuberosa (Anacardiaceae) leaves has antioxidant activity and is an anti-Candida agent by causing mitochondrial and lysosomal damages

England: BioMed Central Ltd

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