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Vertebrate SLRP family evolution and the subfunctionalization of osteoglycin gene duplicates in teleost fish

Costa, R A ; Martins, R S T ; Capilla, E ; Anjos, L ; Power, D M

BMC evolutionary biology, 2018-12, Vol.18 (1), p.191-191, Article 191 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Vertebrate SLRP family evolution and the subfunctionalization of osteoglycin gene duplicates in teleost fish
Autor: Costa, R A ; Martins, R S T ; Capilla, E ; Anjos, L ; Power, D M
Assuntos: Adipocytes ; Aquatic environment ; Biocompatibility ; Biomedical materials ; Bream ; Calcification ; Cell division ; Differentiation ; Evolution ; Extracellular matrix ; Fish ; Gene duplication ; Gene expression ; Genetic aspects ; Genomes ; Genomics ; Kinases ; Leucine ; Mesenchyme ; Musculoskeletal system ; Myocytes ; Myogenesis ; Natural history ; Osteoblastogenesis ; Osteoblasts ; Osteoglycin ; Phylogeny ; Proteins ; Proteoglycans ; Reproduction (copying) ; Skeleton ; SlrP gene ; Small leucine-rich proteoglycan (SLRP) family ; Stem cells ; Teleostei ; Teleosts ; Vertebrates ; Zebrafish
É parte de: BMC evolutionary biology, 2018-12, Vol.18 (1), p.191-191, Article 191
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
Descrição: Osteoglycin (OGN, a.k.a. mimecan) belongs to cluster III of the small leucine-rich proteoglycans (SLRP) of the extracellular matrix (ECM). In vertebrates OGN is a characteristic ECM protein of bone. In the present study we explore the evolution of SLRP III and OGN in teleosts that have a skeleton adapted to an aquatic environment. The SLRP gene family has been conserved since the separation of chondrichthyes and osteichthyes. Few gene duplicates of the SLRP III family exist even in the teleosts that experienced a specific whole genome duplication. One exception is ogn for which duplicate copies were identified in fish genomes. The ogn promoter sequence and in vitro mesenchymal stem cell (MSC) cultures suggest the duplicate ogn genes acquired divergent functions. In gilthead sea bream (Sparus aurata) ogn1 was up-regulated during osteoblast and myocyte differentiation in vitro, while ogn2 was severely down-regulated during bone-derived MSCs differentiation into adipocytes in vitro. Overall, the phylogenetic analysis indicates that the SLRP III family in vertebrates has been under conservative evolutionary pressure. The retention of the ogn gene duplicates in teleosts was linked with the acquisition of different functions. The acquisition by OGN of functions other than that of a bone ECM protein occurred early in the vertebrate lineage.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Vertebrate SLRP family evolution and the subfunctionalization of osteoglycin gene duplicates in teleost fish

Costa, R A ; Martins, R S T ; Capilla, E ; Anjos, L ; Power, D M

England: BioMed Central Ltd

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