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Differing effects of beta-blockers on long-term clinical outcomes following percutaneous coronary intervention between patients with mid-range and reduced left ventricular ejection fraction

Shitara, Jun ; Naito, Ryo ; Kasai, Takatoshi ; Endo, Hirohisa ; Wada, Hideki ; Doi, Shinichiro ; Konishi, Hirokazu ; Tsuboi, Shuta ; Ogita, Manabu ; Dohi, Tomotaka ; Okazaki, Shinya ; Miyauchi, Katsumi ; Daida, Hiroyuki

BMC cardiovascular disorders, 2021-01, Vol.21 (1), p.36-36, Article 36 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Differing effects of beta-blockers on long-term clinical outcomes following percutaneous coronary intervention between patients with mid-range and reduced left ventricular ejection fraction
Autor: Shitara, Jun ; Naito, Ryo ; Kasai, Takatoshi ; Endo, Hirohisa ; Wada, Hideki ; Doi, Shinichiro ; Konishi, Hirokazu ; Tsuboi, Shuta ; Ogita, Manabu ; Dohi, Tomotaka ; Okazaki, Shinya ; Miyauchi, Katsumi ; Daida, Hiroyuki
Assuntos: Acute coronary syndromes ; Adrenergic beta blockers ; Angina pectoris ; Angioplasty ; Beta blockers ; Beta-blocker ; Blood pressure ; Cardiac arrhythmia ; Cardiology ; Care and treatment ; Clinical outcomes ; Coronary artery disease ; Creatinine ; Ejection fraction ; Electrocardiography ; Enzymes ; Family medical history ; Heart attacks ; Heart diseases ; Hospitals ; Hypertension ; Ischemia ; Ischemic heart disease ; Mid-range ejection fraction ; Multivariate analysis ; Myocardial ischemia ; Patient outcomes ; Reduced ejection fraction ; Regression analysis ; Transluminal angioplasty ; Ventricle
É parte de: BMC cardiovascular disorders, 2021-01, Vol.21 (1), p.36-36, Article 36
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: The aim of this study was to determine the difference in effects of beta-blockers on long-term clinical outcomes between ischemic heart disease (IHD) patients with mid-range ejection fraction (mrEF) and those with reduced ejection fraction (rEF). Data were assessed of 3508 consecutive IHD patients who underwent percutaneous coronary intervention (PCI) between 1997 and 2011. Among them, 316 patients with mrEF (EF = 40-49%) and 201 patients with rEF (EF < 40%) were identified. They were assigned to groups according to users and non-users of beta-blockers and effects of beta-blockers were assessed between mrEF and rEF patients, separately. The primary outcome was a composite of all-cause death and non-fatal acute coronary syndrome. The median follow-up period was 5.5 years in mrEF patients and 4.3 years in rEF patients. Cumulative event-free survival was significantly lower in the group with beta-blockers than in the group without beta-blockers in rEF (p = 0.003), whereas no difference was observed in mrEF (p = 0.137) between those with and without beta-blockers. In the multivariate analysis, use of beta-blockers was associated with reduction in clinical outcomes in patients with rEF (hazard ratio (HR), 0.59; 95% confidence interval (CI), 0.36-0.97; p = 0.036), whereas no association was observed among those with mrEF (HR 0.74; 95% CI 0.49-1.10; p = 0.137). Our observational study showed that use of beta-blockers was not associated with long-term clinical outcomes in IHD patients with mrEF, whereas a significant association was observed in those with rEF.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Differing effects of beta-blockers on long-term clinical outcomes following percutaneous coronary intervention between patients with mid-range and reduced left ventricular ejection fraction

Shitara, Jun ; Naito, Ryo ; Kasai, Takatoshi ; Endo, Hirohisa ; Wada, Hideki ; Doi, Shinichiro ; Konishi, Hirokazu ; Tsuboi, Shuta ; Ogita, Manabu ; Dohi, Tomotaka ; Okazaki, Shinya ; Miyauchi, Katsumi ; Daida, Hiroyuki

England: BioMed Central Ltd

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