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Alterations in the CD56 - and CD56 + T Cell Subsets during COVID-19

Vavilova, Julia D ; Ustiuzhanina, Maria O ; Boyko, Anna A ; Streltsova, Maria A ; Kust, Sofya A ; Kanevskiy, Leonid M ; Iskhakov, Rustam N ; Sapozhnikov, Alexander M ; Gubernatorova, Ekaterina O ; Drutskaya, Marina S ; Bychinin, Mikhail V ; Novikova, Oksana N ; Sotnikova, Anna G ; Yusubalieva, Gaukhar M ; Baklaushev, Vladimir P ; Kovalenko, Elena I

International journal of molecular sciences, 2023-05, Vol.24 (10), p.9047 [Peer Reviewed Journal]

Switzerland: MDPI AG

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Title:
Alterations in the CD56 - and CD56 + T Cell Subsets during COVID-19
Author: Vavilova, Julia D ; Ustiuzhanina, Maria O ; Boyko, Anna A ; Streltsova, Maria A ; Kust, Sofya A ; Kanevskiy, Leonid M ; Iskhakov, Rustam N ; Sapozhnikov, Alexander M ; Gubernatorova, Ekaterina O ; Drutskaya, Marina S ; Bychinin, Mikhail V ; Novikova, Oksana N ; Sotnikova, Anna G ; Yusubalieva, Gaukhar M ; Baklaushev, Vladimir P ; Kovalenko, Elena I
Subjects: Antiviral activity ; Antiviral agents ; Biomarkers ; Blood ; CD16 antigen ; CD56 antigen ; CD56+ T cells ; CD8 antigen ; CD8-Positive T-Lymphocytes ; Cell activation ; Cell death ; Cell Differentiation ; Coronaviruses ; COVID-19 ; COVID-19 - metabolism ; Cytokine storm ; Cytotoxicity ; Differentiation ; Disease ; Evaluation ; Genotype & phenotype ; Health aspects ; HLA-DR ; Humans ; Infections ; Killer Cells, Natural ; Lymphocytes ; Lymphocytes T ; Natural killer cells ; NKG2 antigen ; NKT-like cells ; Pandemics ; PD-1 protein ; PD1 ; Plasma ; Potassium channels (inwardly-rectifying) ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; T cell receptors ; T cells ; T-Lymphocyte Subsets
Is Part Of: International journal of molecular sciences, 2023-05, Vol.24 (10), p.9047
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Description: The effectiveness of the antiviral immune response largely depends on the activation of cytotoxic T cells. The heterogeneous group of functionally active T cells expressing the CD56 molecule (NKT-like cells), that combines the properties of T lymphocytes and NK cells, is poorly studied in COVID-19. This work aimed to analyze the activation and differentiation of both circulating NKT-like cells and CD56 T cells during COVID-19 among intensive care unit (ICU) patients, moderate severity (MS) patients, and convalescents. A decreased proportion of CD56 T cells was found in ICU patients with fatal outcome. Severe COVID-19 was accompanied by a decrease in the proportion of CD8 T cells, mainly due to the CD56 cell death, and a redistribution of the NKT-like cell subset composition with a predominance of more differentiated cytotoxic CD8 T cells. The differentiation process was accompanied by an increase in the proportions of KIR2DL2/3 and NKp30 cells in the CD56 T cell subset of COVID-19 patients and convalescents. Decreased percentages of NKG2D and NKG2A cells and increased PD-1 and HLA-DR expression levels were found in both CD56 and CD56 T cells, and can be considered as indicators of COVID-19 progression. In the CD56 T cell fraction, increased CD16 levels were observed in MS patients and in ICU patients with lethal outcome, suggesting a negative role for CD56 CD16 T cells in COVID-19. Overall, our findings suggest an antiviral role of CD56 T cells in COVID-19.
Publisher: Switzerland: MDPI AG
Language: English

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Alterations in the CD56 - and CD56 + T Cell Subsets during COVID-19

Switzerland: MDPI AG

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