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Surface Modification of Additively Fabricated Titanium-Based Implants by Means of Bioactive Micro-Arc Oxidation Coatings for Bone Replacement

Kozelskaya, Anna I ; Rutkowski, Sven ; Frueh, Johannes ; Gogolev, Aleksey S ; Chistyakov, Sergei G ; Gnedenkov, Sergey V ; Sinebryukhov, Sergey L ; Frueh, Andreas ; Egorkin, Vladimir S ; Choynzonov, Evgeny L ; Buldakov, Mikhail ; Kulbakin, Denis E ; Bolbasov, Evgeny N ; Gryaznov, Anton P ; Verzunova, Ksenia N ; Apostolova, Margarita D ; Tverdokhlebov, Sergei I

Journal of functional biomaterials, 2022-12, Vol.13 (4), p.285 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Surface Modification of Additively Fabricated Titanium-Based Implants by Means of Bioactive Micro-Arc Oxidation Coatings for Bone Replacement
Autor: Kozelskaya, Anna I ; Rutkowski, Sven ; Frueh, Johannes ; Gogolev, Aleksey S ; Chistyakov, Sergei G ; Gnedenkov, Sergey V ; Sinebryukhov, Sergey L ; Frueh, Andreas ; Egorkin, Vladimir S ; Choynzonov, Evgeny L ; Buldakov, Mikhail ; Kulbakin, Denis E ; Bolbasov, Evgeny N ; Gryaznov, Anton P ; Verzunova, Ksenia N ; Apostolova, Margarita D ; Tverdokhlebov, Sergei I
Assuntos: 3-D printers ; Additive manufacturing ; additively manufactured metal implants ; Alloys ; bioactive coatings ; Biocompatibility ; Biological effects ; Biological properties ; Bone implants ; Bones ; Calcium oxide ; Calcium phosphate ; calcium phosphate coatings ; Calcium phosphates ; Cell adhesion ; Cell differentiation ; Cell growth ; Cell proliferation ; Coatings ; Computed tomography ; Corrosion and anti-corrosives ; Corrosion prevention ; Corrosion tests ; Crystallites ; Crystals ; CT imaging ; Differentiation (biology) ; Electrochemistry ; Electrolytes ; Electrolytic cells ; Laser sintering ; Lime ; Methods ; micro-arc oxidation ; Morphology ; Oxidation ; Oxidation process ; Phase composition ; Phosphorus ; Process parameters ; Protective coatings ; Quality control ; Rapid prototyping ; Scientific equipment and supplies industry ; Software ; Stem cells ; Surgical implants ; Titanium ; Tomography ; Transplants & implants ; X-ray computed tomography
É parte de: Journal of functional biomaterials, 2022-12, Vol.13 (4), p.285
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: In this work, the micro-arc oxidation method is used to fabricate surface-modified complex-structured titanium implant coatings to improve biocompatibility. Depending on the utilized electrolyte solution and micro-arc oxidation process parameters, three different types of coatings (one of them-oxide, another two-calcium phosphates) were obtained, differing in their coating thickness, crystallite phase composition and, thus, with a significantly different biocompatibility. An analytical approach based on X-ray computed tomography utilizing software-aided coating recognition is employed in this work to reveal their structural uniformity. Electrochemical studies prove that the coatings exhibit varying levels of corrosion protection. and experiments of the three different micro-arc oxidation coatings prove high biocompatibility towards adult stem cells (investigation of cell adhesion, proliferation and osteogenic differentiation), as well as biocompatibility (including histological analysis). These results demonstrate superior biological properties compared to unmodified titanium surfaces. The ratio of calcium and phosphorus in coatings, as well as their phase composition, have a great influence on the biological response of the coatings.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Surface Modification of Additively Fabricated Titanium-Based Implants by Means of Bioactive Micro-Arc Oxidation Coatings for Bone Replacement

Switzerland: MDPI AG

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