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Evaluation of oral mucositis, candidiasis, and quality of life in patients with head and neck cancer treated with a hypofractionated or conventional radiotherapy protocol: a longitudinal, prospective, observational study

de Vasconcellos Ferreira, Pedro Maciel ; Gomes, Marina de Castro Monteiro Franco ; Almeida, Ana Clara Speziali Menegazzi ; Cornélio, Júlia Soares ; Arruda, Thiago Jardim ; Mafra, Arnoldo ; Nunes, Marcelo Henrique Silva ; Salera, Rafael Borges ; Nogueira, Raquel Fabiane ; Sclauser, Juliana Maria Braga ; Drummond-Lage, Ana Paula ; Rezende, Bruno Almeida

Head & face medicine, 2023-03, Vol.19 (1), p.7-7, Article 7 [Peer Reviewed Journal]

England: BioMed Central Ltd

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Title:
Evaluation of oral mucositis, candidiasis, and quality of life in patients with head and neck cancer treated with a hypofractionated or conventional radiotherapy protocol: a longitudinal, prospective, observational study
Author: de Vasconcellos Ferreira, Pedro Maciel ; Gomes, Marina de Castro Monteiro Franco ; Almeida, Ana Clara Speziali Menegazzi ; Cornélio, Júlia Soares ; Arruda, Thiago Jardim ; Mafra, Arnoldo ; Nunes, Marcelo Henrique Silva ; Salera, Rafael Borges ; Nogueira, Raquel Fabiane ; Sclauser, Juliana Maria Braga ; Drummond-Lage, Ana Paula ; Rezende, Bruno Almeida
Subjects: Analysis ; Cancer patients ; Cancer therapies ; Candidiasis ; Candidiasis - complications ; Care and treatment ; Coronaviruses ; COVID-19 ; Epidemics ; Head & neck cancer ; Head and neck cancer ; Head and Neck Neoplasms ; Head and Neck Neoplasms - radiotherapy ; Health aspects ; Humans ; Medical centers ; Mucositis - complications ; Observational studies ; Observational Studies as Topic ; Oral Candidiasis ; Oral Mucositis ; Prospective Studies ; Quality of Life ; Radiation Dose Hypofractionation ; Radiotherapy ; Radiotherapy Dose Fractionations ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Stomatitis ; Stomatitis - drug therapy ; Stomatitis - epidemiology ; Stomatitis - etiology ; World health
Is Part Of: Head & face medicine, 2023-03, Vol.19 (1), p.7-7, Article 7
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: Due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, recently, Radiotherapy (RT) protocols requiring fewer sessions (hypofractionated) have been used to shorten RT treatment and minimize patient exposure to medical centers, and decrease the risk of SARS-CoV-2 infection. This longitudinal, prospective, observational study aimed to compare the quality of life (QoL) and the incidence of oral mucositis and candidiasis in 66 patients with head and neck cancer (HNC) who undergo a hypofractionated RT protocol (GHipo), total of 55 Gy for 4 weeks, or a conventional RT protocol (GConv), total of 66 - 70 Gy for 6 - 7 weeks. To assess the incidence and severity of oral mucositis, the incidence of candidiasis, and QoL were evaluated using the World Health Organization scale, clinical evaluation, and the QLC-30 and H&N-35 questionnaires, respectively, at the beginning and the end of RT. The incidence of candidiasis did not show differences between the two groups. However, at the end of RT, mucositis had a higher incidence (p < 0.01) and severity (p < 0.05) in GHipo. QoL was not markedly different between the two groups. Although mucositis worsened in patients treated with hypofractionated RT, QoL did not worsen for patients on this regimen. Our results open perspectives for the potential use of RT protocols for HNC with fewer sessions in conditions that require faster, cheaper, and more practical treatments.
Publisher: England: BioMed Central Ltd
Language: English

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Evaluation of oral mucositis, candidiasis, and quality of life in patients with head and neck cancer treated with a hypofractionated or conventional radiotherapy protocol: a longitudinal, prospective, observational study

England: BioMed Central Ltd

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