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The diagnostic value of circulating microRNAs for middle-aged (40–60-year-old) coronary artery disease patients

Md Sayed, Ali Sheikh ; Xia, Ke ; Li, Fei ; Deng, Xu ; Salma, Umme ; Li, Tingbo ; Deng, Hai ; Yang, Dafeng ; Haoyang, Zhou ; Yang, TianLun ; Peng, Jun

Clinics (São Paulo, Brazil), 2015-04, Vol.70 (4), p.257-263 [Revista revisada por pares]

Brazil: Elsevier España, S.L.U

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  • Título:
    The diagnostic value of circulating microRNAs for middle-aged (40–60-year-old) coronary artery disease patients
  • Autor: Md Sayed, Ali Sheikh ; Xia, Ke ; Li, Fei ; Deng, Xu ; Salma, Umme ; Li, Tingbo ; Deng, Hai ; Yang, Dafeng ; Haoyang, Zhou ; Yang, TianLun ; Peng, Jun
  • Materias: Age Factors ; Biomarkers ; Biomarkers - blood ; Case-Control Studies ; Circulating microRNAs ; Clinical Science ; Coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnosis ; Female ; Humans ; Male ; MEDICINE, GENERAL & INTERNAL ; MicroRNAs - blood ; Middle Aged ; Non-coronary artery disease ; Real-Time Polymerase Chain Reaction ; Reference Values ; Reproducibility of Results ; Sensitivity and Specificity ; Unstable angina
  • Es parte de: Clinics (São Paulo, Brazil), 2015-04, Vol.70 (4), p.257-263
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Sayed AS and Xia K designed the research, performed the experiments and wrote the manuscript. Deng X, Deng H, Yangda F, Li F, Haoyang Z, Li T, and Salma U collected patient samples and assembled the data. Yang T and Peng J supervised the data analysis and revised the manuscript. The work presented in this paper was performed in collaboration with all the authors.
  • Descripción: Circulating microRNAs have been recognized as promising biomarkers for various diseases. The present study aimed to explore the potential roles of circulating miR-149, miR-424 and miR-765 as non-invasive biomarkers for the diagnosis of coronary artery disease in middle-aged (40–60-year-old) patients. Sixty-five stable coronary artery disease patients (49–57 years old), 30 unstable coronary artery disease patients (49–58 years old), and 32 non-coronary artery disease patients (49–-57 years old) who were matched for age, sex, smoking habits, hypertension and diabetes were enrolled in this study. Total RNA was isolated from plasma with TRIzol reagent. Circulating miRNA levels were measured by quantitative real-time polymerase chain reaction. Circulating miR-149 levels were decreased 4.49-fold in stable coronary artery disease patients (1.18 ± 0.84) and 5.09-fold in unstable coronary artery disease patients (1.04 ± 0.65) compared with non-coronary artery disease patients (5.30 ± 2.57) (p<0.001). Circulating miR-424 levels were reduced 3.6-fold in stable coronary artery disease patients (1.18 ± 0.60) and 5-fold in unstable coronary artery disease patients (0.86 ± 0.54) compared with non-coronary artery disease patients (4.35 ± 2.20) (p<0.001). In contrast, circulating miR-765 levels were elevated 3.98-fold in stable coronary artery disease patients (6.09 ± 2.27) and 5.33-fold in unstable coronary artery disease patients (8.17 ± 2.77) compared with non-coronary artery disease patients (1.53 ± 0.99) (p<0.001). Receiver operating characteristic curve analysis revealed that the respective areas under the curve for circulating miR-149, miR-424 and miR-765 were 0.938, 0.919 and 0.968 in stable CAD patients and 0.951, 0.960 and 0.977 in unstable coronary artery disease patients compared with non-coronary artery disease patients. Our results suggest that circulating miR-149, miR-424 and miR-765 might be novel, non-invasive biomarkers for the diagnosis of coronary artery disease in middle-aged patients. However, future prospective trials in large patient cohorts are necessary before reaching a solid conclusion.
  • Editor: Brazil: Elsevier España, S.L.U
  • Idioma: Inglés;Portugués
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