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The burden of persistent symptoms after COVID-19 (long COVID): a meta-analysis of controlled studies in children and adults

Azzam, Ahmed ; Khaled, Heba ; Refaey, Neveen ; Mohsen, Shorouk ; El-Emam, Ola Ali ; Dawood, Nada ; Ahmed, Hebatalla A ; Soliman, Omar A ; Mostafa, Sana ; Ramadan, Heba ; Mosa, Maha ; Elmowafy, Amora Omar Ibrahim ; Rizk, Shimaa Mohamed Abdou ; Zaki, Ahmed ; Hussien, Mostafa ; Ahmed, Ameer ; Ezzat, Ahmad Ashraf ; Hassan, Fatma E

Virology journal, 2024-01, Vol.21 (1), p.16-16, Article 16 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
The burden of persistent symptoms after COVID-19 (long COVID): a meta-analysis of controlled studies in children and adults
Autor: Azzam, Ahmed ; Khaled, Heba ; Refaey, Neveen ; Mohsen, Shorouk ; El-Emam, Ola Ali ; Dawood, Nada ; Ahmed, Hebatalla A ; Soliman, Omar A ; Mostafa, Sana ; Ramadan, Heba ; Mosa, Maha ; Elmowafy, Amora Omar Ibrahim ; Rizk, Shimaa Mohamed Abdou ; Zaki, Ahmed ; Hussien, Mostafa ; Ahmed, Ameer ; Ezzat, Ahmad Ashraf ; Hassan, Fatma E
Assuntos: Adult ; Ageusia - etiology ; Anosmia ; Anosmia - etiology ; Child ; Chronic obstructive pulmonary disease ; Comorbidity ; Comparative analysis ; COVID-19 ; COVID-19 - complications ; COVID-19 - epidemiology ; Dyspnea ; Health aspects ; Hospitalization ; Humans ; Infections ; Medical research ; Medicine, Experimental ; Meta-analysis ; Pandemics ; Population studies ; Post-Acute COVID-19 Syndrome - complications ; Post-Acute COVID-19 Syndrome - epidemiology ; Respiration ; Severe acute respiratory syndrome coronavirus 2 ; Systematic review
É parte de: Virology journal, 2024-01, Vol.21 (1), p.16-16, Article 16
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Previous meta-analyses estimating the prevalence of the post-COVID-19 condition (PCC) were confounded by the lack of negative control groups. This may result in an overestimation of the prevalence of those experiencing PCC, as these symptoms are non-specific and common in the general population. In this study, we aimed to compare the burden of persistent symptoms among COVID-19 survivors relative to COVID-19-negative controls. A systematic literature search was conducted using the following databases (PubMed, Web of Science, and Scopus) until July 2023 for comparative studies that examined the prevalence of persistent symptoms in COVID-19 survivors. Given that many of the symptoms among COVID-19 survivors overlap with post-hospitalization syndrome and post-intensive care syndrome, we included studies that compare the prevalence of persistent symptoms in hospitalized COVID-19 patients relative to non-COVID-19 hospitalized patients and in non-hospitalized COVID-19 patients relative to healthy controls that reported outcomes after at least 3 months since infection. The results of the meta-analysis were reported as odds ratios with a 95% confidence interval based on the random effects model. Twenty articles were included in this study. Our analysis of symptomatology in non-hospitalized COVID-19 patients compared to negative controls revealed that the majority of symptoms examined were not related to COVID-19 infection and appeared equally prevalent in both cohorts. However, non-COVID-19 hospitalized patients had higher odds of occurrence of certain symptoms like anosmia, ageusia, fatigue, dyspnea, and brain fog (P < 0.05). Particularly, anosmia and ageusia showed substantially elevated odds relative to the negative control group at 11.27 and 9.76, respectively, P < 0.05. In contrast, analysis of hospitalized COVID-19 patients compared to those hospitalized for other indications did not demonstrate significantly higher odds for the tested symptoms. The persistent symptoms in COVID-19 survivors may result from hospitalization for causes unrelated to COVID-19 and are commonly reported among the general population. Although certain symptoms exhibited higher odds in non-hospitalized COVID-19 patients relative to controls, these symptoms are common post-viral illnesses. Therefore, the persistent symptoms after COVID-19 may not be unique to SARS-CoV-2. Future studies including well-matched control groups when investigating persistent symptoms in COVID-19 survivors are warranted to draw a firm conclusion.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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The burden of persistent symptoms after COVID-19 (long COVID): a meta-analysis of controlled studies in children and adults

England: BioMed Central Ltd

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