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Lignans from Tujia Ethnomedicine Heilaohu: Chemical Characterization and Evaluation of Their Cytotoxicity and Antioxidant Activities

Liu, Yongbei ; Yang, Yupei ; Tasneem, Shumaila ; Hussain, Nusrat ; Daniyal, Muhammad ; Yuan, Hanwen ; Xie, Qingling ; Liu, Bin ; Sun, Jing ; Jian, Yuqing ; Li, Bin ; Chen, Shenghuang ; Wang, Wei

Molecules (Basel, Switzerland), 2018-08, Vol.23 (9), p.2147 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Lignans from Tujia Ethnomedicine Heilaohu: Chemical Characterization and Evaluation of Their Cytotoxicity and Antioxidant Activities
Autor: Liu, Yongbei ; Yang, Yupei ; Tasneem, Shumaila ; Hussain, Nusrat ; Daniyal, Muhammad ; Yuan, Hanwen ; Xie, Qingling ; Liu, Bin ; Sun, Jing ; Jian, Yuqing ; Li, Bin ; Chen, Shenghuang ; Wang, Wei
Assuntos: Anti-inflammatory agents ; antioxidant ; Antioxidants ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Cancer ; Cell Line ; Cell Survival - drug effects ; chemical characterization ; Chemiluminescence ; Cotton ; Cytotoxicity ; Ethnomedicine ; heilaohu ; Humans ; Hydrocarbons ; Inflammation ; Lignans ; Lignans - chemistry ; Lignans - pharmacology ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Structure ; Organic chemistry ; Oxidants ; Oxidizing agents ; Phytochemicals - chemistry ; Phytochemicals - pharmacology ; Planar structures ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; tujia ethnomedicine
É parte de: Molecules (Basel, Switzerland), 2018-08, Vol.23 (9), p.2147
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
Descrição: Heilaohu, the roots of has a long history of use in Tujia ethnomedicine for the treatment of rheumatoid arthritis and gastroenteric disorders, and a lot of work has been done in order to know the material basis of its pharmacological activities. The chemical investigation led to the isolation and characterization of three new ( ⁻ ) and twenty known ( ⁻ ) lignans. Three new heilaohulignans A-C ( ⁻ ) and seventeen known ( ⁻ ) lignans possessed dibenzocyclooctadiene skeletons. Similarly, one was a diarylbutane ( ) and two were spirobenzofuranoid dibenzocyclooctadiene ( ⁻ ) lignans. Among the known compounds, ⁻ , , ⁻ and ⁻ were isolated from this species for the first time. The structures were established, using IR, UV, MS and NMR data. The absolute configurations of the new compounds were determined by circular dichroism (CD) spectra. The isolated lignans were further evaluated for their cytotoxicity and antioxidant activities. Compound demonstrated strong cytotoxic activity with an IC value of 9.92 µM, compounds and revealed weak cytotoxicity with IC values of 21.72 µM and 18.72 µM, respectively in the HepG-2 human liver cancer cell line. Compound also showed weak cytotoxicity against the BGC-823 human gastric cancer cell line and the HCT-116 human colon cancer cell line with IC values of 16.75 µM and 16.59 µM, respectively. A chemiluminescence assay for antioxidant status of isolated compounds implied compounds and which showed weak activity with IC values of 25.56 µM and 21.20 µM, respectively.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Lignans from Tujia Ethnomedicine Heilaohu: Chemical Characterization and Evaluation of Their Cytotoxicity and Antioxidant Activities

Liu, Yongbei ; Yang, Yupei ; Tasneem, Shumaila ; Hussain, Nusrat ; Daniyal, Muhammad ; Yuan, Hanwen ; Xie, Qingling ; Liu, Bin ; Sun, Jing ; Jian, Yuqing ; Li, Bin ; Chen, Shenghuang ; Wang, Wei

Switzerland: MDPI AG

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