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The X-X-/E+E+ genotype of the XbaI/EcoRI polymorphisms of the apolipoprotein B gene as a marker of coronary artery disease in a Brazilian sample

Scartezini, M ; Zago, M A ; Chautard-Freire-Maia, E A ; Pazin-Filho, A ; Marin-Neto, J A ; Hotta, J K S ; Nascimento, A J ; Dos-Santos, J E

Brazilian journal of medical and biological research, 2003-03, Vol.36 (3), p.369-375 [Periódico revisado por pares]

Brazil: Associação Brasileira de Divulgação Científica

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Título:
The X-X-/E+E+ genotype of the XbaI/EcoRI polymorphisms of the apolipoprotein B gene as a marker of coronary artery disease in a Brazilian sample
Autor: Scartezini, M ; Zago, M A ; Chautard-Freire-Maia, E A ; Pazin-Filho, A ; Marin-Neto, J A ; Hotta, J K S ; Nascimento, A J ; Dos-Santos, J E
Assuntos: Adult ; Alleles ; Apo B XbaI/EcoRI polymorphisms ; Apolipoproteins B - genetics ; BIOLOGY ; CAD risk ; Case-Control Studies ; Coronary artery disease ; Coronary Disease - genetics ; Cross-Sectional Studies ; Deoxyribonuclease EcoRI - genetics ; Deoxyribonucleases, Type II Site-Specific - genetics ; Female ; Genetic Markers ; Genotype ; Humans ; Male ; MEDICINE, RESEARCH & EXPERIMENTAL ; Middle Aged ; Multivariate Analysis ; Polymorphism, Genetic - genetics ; Polymorphism, Restriction Fragment Length ; Prospective Studies ; Risk Factors
É parte de: Brazilian journal of medical and biological research, 2003-03, Vol.36 (3), p.369-375
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Studies that consider polymorphisms within the apolipoprotein B (apo B) gene as risk factors for coronary artery disease (CAD) have reported conflicting results. The aim of the present study was to search for associations between two DNA RFLPs (XbaI and EcoRI) of the apo B gene and CAD diagnosed by angiography. In the present study we compared 116 Brazilian patients (92 men) with CAD (CAD+) to 78 control patients (26 men) without ischemia or arterial damage (CAD-). The allele frequencies at the XbaI (X) and EcoRI (E) sites did not differ between groups. The genotype distributions of CAD+ and CAD- patients were different (chi (1) = 6.27, P = 0.012) when assigned to two classes (X-X-/E+E+ and the remaining XbaI/EcoRI genotypes). Multivariate logistic regression analysis showed that individuals with the X-X-/E+E+ genotype presented a 6.1 higher chance of developing CAD than individuals with the other XbaI/EcoRI genotypes, independently of the other risk factors considered (sex, tobacco consumption, total cholesterol, hypertension, and triglycerides). We conclude that the X-X-/E+E genotype may be in linkage disequilibrium with an unknown variation in the apo B gene or with a variation in another gene that affects the risk of CAD.
Editor: Brazil: Associação Brasileira de Divulgação Científica
Idioma: Inglês;Português

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The X-X-/E+E+ genotype of the XbaI/EcoRI polymorphisms of the apolipoprotein B gene as a marker of coronary artery disease in a Brazilian sample

Scartezini, M ; Zago, M A ; Chautard-Freire-Maia, E A ; Pazin-Filho, A ; Marin-Neto, J A ; Hotta, J K S ; Nascimento, A J ; Dos-Santos, J E

Brazil: Associação Brasileira de Divulgação Científica

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