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Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

Hayakawa, Sumio ; Ohishi, Tomokazu ; Miyoshi, Noriyuki ; Oishi, Yumiko ; Nakamura, Yoriyuki ; Isemura, Mamoru

Molecules (Basel, Switzerland), 2020-10, Vol.25 (19), p.4553 [Peer Reviewed Journal]

Switzerland: MDPI AG

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Title:
Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid
Author: Hayakawa, Sumio ; Ohishi, Tomokazu ; Miyoshi, Noriyuki ; Oishi, Yumiko ; Nakamura, Yoriyuki ; Isemura, Mamoru
Subjects: Acids ; Animals ; Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - therapeutic use ; Antioxidants - chemistry ; Antioxidants - therapeutic use ; Caffeine ; Cancer ; Catechin - analogs & derivatives ; Catechin - chemistry ; Catechin - therapeutic use ; Chlorogenic acid ; Chlorogenic Acid - chemistry ; Chlorogenic Acid - therapeutic use ; Coffee ; Coffee - chemistry ; Consumption ; EGCG ; Epidemiology ; Epigallocatechin gallate ; Esophagus ; Green tea ; Human papillomavirus ; Humans ; Kinases ; Leukemia ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Neoplasms - pathology ; Polyphenols ; Prostate ; Review ; ROS ; Tea ; Tea - chemistry ; Tumor necrosis factor-TNF ; Warts
Is Part Of: Molecules (Basel, Switzerland), 2020-10, Vol.25 (19), p.4553
Description: Tea and coffee are consumed worldwide and epidemiological and clinical studies have shown their health beneficial effects, including anti-cancer effects. Epigallocatechin gallate (EGCG) and chlorogenic acid (CGA) are the major components of green tea polyphenols and coffee polyphenols, respectively, and believed to be responsible for most of these effects. Although a large number of cell-based and animal experiments have provided convincing evidence to support the anti-cancer effects of green tea, coffee, EGCG, and CGA, human studies are still controversial and some studies have suggested even an increased risk for certain types of cancers such as esophageal and gynecological cancers with green tea consumption and bladder and lung cancers with coffee consumption. The reason for these inconsistent results may have been arisen from various confounding factors. Cell-based and animal studies have proposed several mechanisms whereby EGCG and CGA exert their anti-cancer effects. These components appear to share the common mechanisms, among which one related to reactive oxygen species is perhaps the most attractive. Meanwhile, EGCG and CGA have also different target molecules which might explain the site-specific differences of anti-cancer effects found in human studies. Further studies will be necessary to clarify what is the mechanism to cause such differences between green tea and coffee.
Publisher: Switzerland: MDPI AG
Language: English

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Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

Hayakawa, Sumio ; Ohishi, Tomokazu ; Miyoshi, Noriyuki ; Oishi, Yumiko ; Nakamura, Yoriyuki ; Isemura, Mamoru

Switzerland: MDPI AG

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