skip to main content
Idioma:

Developing Antimicrobial Synergy With AMPs

Duong, Leora ; Gross, Steven P ; Siryaporn, Albert

Frontiers in medical technology, 2021-03, Vol.3, p.640981-640981 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

Texto completo disponível

Citações Citado por
  • Título:
    Developing Antimicrobial Synergy With AMPs
  • Autor: Duong, Leora ; Gross, Steven P ; Siryaporn, Albert
  • Assuntos: antibiotic resistance ; antimicrobial peptides ; antimicrobial synergism ; histones ; intracellular targeting ; Medical Technology
  • É parte de: Frontiers in medical technology, 2021-03, Vol.3, p.640981-640981
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Edited by: Sattar Taheri-Araghi, California State University, Northridge, United States
    This article was submitted to Pharmaceutical Innovation, a section of the journal Frontiers in Medical Technology
    Reviewed by: Laura Orian, University of Padua, Italy; Dario Spelzini, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
  • Descrição: Antimicrobial peptides (AMPs) have been extensively studied due to their vast natural abundance and ability to kill microbes. In an era critically lacking in new antibiotics, manipulating AMPs for therapeutic application is a promising option. However, bacterial pathogens resistant to AMPs remain problematic. To improve AMPs antimicrobial efficacy, their use in conjunction with other antimicrobials has been proposed. How might this work? AMPs kill bacteria by forming pores in bacterial membranes or by inhibiting bacterial macromolecular functions. What remains unknown is the duration for which AMPs keep bacterial pores open, and the extent to which bacteria can recover by repairing these pores. In this mini-review, we discuss various antimicrobial synergies with AMPs. Such synergies might arise if the antimicrobial agents helped to keep bacterial pores open for longer periods of time, prevented pore repair, perturbed bacterial intracellular functions at greater levels, or performed other independent bacterial killing mechanisms. We first discuss combinations of AMPs, and then focus on histones, which have antimicrobial activity and co-localize with AMPs on lipid droplets and in neutrophil extracellular traps (NETs). Recent work has demonstrated that histones can enhance AMP-induced membrane permeation. It is possible that histones, histone fragments, and histone-like peptides could amplify the antimicrobial effects of AMPs, giving rise to antimicrobial synergy. If so, clarifying these mechanisms will thus improve our overall understanding of the antimicrobial processes and potentially contribute to improved drug design.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.