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PDS5A and PDS5B in Cohesin Function and Human Disease

Zhang, Nenggang ; Coutinho, Luiza E. ; Pati, Debananda

International journal of molecular sciences, 2021-05, Vol.22 (11), p.5868 [Periódico revisado por pares]

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Título:
PDS5A and PDS5B in Cohesin Function and Human Disease
Autor: Zhang, Nenggang ; Coutinho, Luiza E. ; Pati, Debananda
Assuntos: cancer ; cohesin ; cohesinopathy ; PDS5A ; PDS5B ; Review
É parte de: International journal of molecular sciences, 2021-05, Vol.22 (11), p.5868
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Precocious dissociation of sisters 5 (PDS5) is an associate protein of cohesin that is conserved from yeast to humans. It acts as a regulator of the cohesin complex and plays important roles in various cellular processes, such as sister chromatid cohesion, DNA damage repair, gene transcription, and DNA replication. Vertebrates have two paralogs of PDS5, PDS5A and PDS5B, which have redundant and unique roles in regulating cohesin functions. Herein, we discuss the molecular characteristics and functions of PDS5, as well as the effects of its mutations in the development of diseases and their relevance for novel therapeutic strategies.
Editor: MDPI
Idioma: Inglês

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