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Development of an amoxicillin-radix scutellaria extract formulation and evaluation of its pharmacokinetics in pigs

Yi, Dandan ; Wen, Xuemei ; Xu, Wei ; Xu, Yangfeng ; Deng, Xin ; Yan, Guoqing ; Wu, Liqin ; Liang, Qiuling ; Liang, Zhengmin ; Peng, Jianbo ; He, Jiakang

BMC veterinary research, 2023-09, Vol.19 (1), p.1-164, Article 164 [Peer Reviewed Journal]

London: BioMed Central Ltd

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Title:
Development of an amoxicillin-radix scutellaria extract formulation and evaluation of its pharmacokinetics in pigs
Author: Yi, Dandan ; Wen, Xuemei ; Xu, Wei ; Xu, Yangfeng ; Deng, Xin ; Yan, Guoqing ; Wu, Liqin ; Liang, Qiuling ; Liang, Zhengmin ; Peng, Jianbo ; He, Jiakang
Subjects: Amoxicillin ; Analysis ; Antibiotics ; Antimicrobial agents ; Bacterial infections ; Bacteriosis ; Baicalin ; Bioavailability ; Care and treatment ; Clinical trials ; Complications and side effects ; Density ; Drug dosages ; Drug resistance ; E coli ; Escherichia coli ; Glucose ; Health aspects ; Herbal medicine ; Hogs ; Humidity ; Minimum inhibitory concentration ; Moisture absorption ; Oral administration ; Oxytetracycline ; Patient outcomes ; Pharmaceutical industry ; Pharmacokinetics ; Pig ; Plasma ; Powder ; Powders ; Quality control ; Radix scutellaria extract ; Salmonella ; Sensitivity analysis ; Staphylococcus aureus ; Staphylococcus aureus infections ; Staphylococcus infections ; Statistical analysis ; Streptococcus ; Swine ; Veterinary medicine ; Virulence
Is Part Of: BMC veterinary research, 2023-09, Vol.19 (1), p.1-164, Article 164
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: Abstract Background A new antibacterial compound powder of amoxicillin (AMO)/Radix Scutellaria extract (RSE) was developed, and its pharmacokinetics were determined in pigs following oral administration. Results The MIC ranges of AMO against Escherichia coli , Staphylococcus aureus and Streptococcus were 1–8 μg/mL, 0.5–4 μg/mL and 0.5–64 μg/mL, respectively. The MIC ranges of RSE against E. coli , S. aureus , and Streptococcus were greater than 2.5 mg/mL, 0.156–2.5 mg/mL, and greater than 2.5 mg/mL, respectively. For S. aureus , the combined drug susceptibility test showed that AMO and RSE had an additive or synergistic effect. The results of compatibility test, the excipient screening test and the drug quality control test showed that the formulation had stable quality and uniform properties under the test conditions. Two studies were conducted to investigate the pharmacokinetics of the compound product in pigs. First, the pharmacokinetics of the AMO-RSE powder were compared with those of their respective single products. The results showed no significant change in the main pharmacokinetic parameters when either component was removed from the compound formulation; thus, AMO and RSE have no pharmacokinetic interaction in pigs. Second, pigs were orally administered three different doses of AMO-RSE powder. The Cmax and AUC increased proportionally with increasing p.o. dose; thus, the λ z , t 1/2λ , MRT, and T max were unchanged for the doses of 10, 20, and 30 mg/kg AMO and the doses of 5, 10, and 15 mg/kg BCL, showing that AMO/baicalin in AMO-RSE powder showed linear pharmacokinetic characteristics in pigs. Conclusions The combined drug sensitivity test of AMO and RSE against S. aureus showed that the combination was additive or synergistic. Pharmacokinetic studies indicated that AMO and BCL do not interfere with each other in pigs when used in a compound formulation. The pharmacokinetic parameters remained unchanged regardless of the dose for p.o. administration, indicating linear pharmacokinetic properties over the tested dose range. The quality of the AMO-RSE powder was good and stable, providing a foundation for its clinical application in veterinary medicine. Further bioavailability, PK/PD and clinical trials are still needed to determine the final dosage regimen.
Publisher: London: BioMed Central Ltd
Language: English

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Development of an amoxicillin-radix scutellaria extract formulation and evaluation of its pharmacokinetics in pigs

Yi, Dandan ; Wen, Xuemei ; Xu, Wei ; Xu, Yangfeng ; Deng, Xin ; Yan, Guoqing ; Wu, Liqin ; Liang, Qiuling ; Liang, Zhengmin ; Peng, Jianbo ; He, Jiakang

London: BioMed Central Ltd

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