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Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Dhatchinamoorthy, Karthik ; Colbert, Jeff D ; Rock, Kenneth L

Frontiers in immunology, 2021-03, Vol.12, p.636568 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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Título:
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation
Autor: Dhatchinamoorthy, Karthik ; Colbert, Jeff D ; Rock, Kenneth L
Assuntos: Animals ; Antigen Presentation ; cancer immune evasion ; Gene Deletion ; Gene Expression Regulation, Neoplastic ; Histocompatibility Antigens Class I - genetics ; Histocompatibility Antigens Class I - immunology ; Histocompatibility Antigens Class I - metabolism ; Humans ; Immunology ; interferon ; Killer Cells, Natural - immunology ; Killer Cells, Natural - metabolism ; Lymphocytes, Tumor-Infiltrating - immunology ; Lymphocytes, Tumor-Infiltrating - metabolism ; MHC I antigen presentation ; Mutation ; Neoplasms - genetics ; Neoplasms - immunology ; Neoplasms - metabolism ; Signal Transduction ; TAP1 ; Tapasin ; Transcription, Genetic ; Tumor Escape ; Tumor Microenvironment
É parte de: Frontiers in immunology, 2021-03, Vol.12, p.636568
Notas: This article was submitted to Antigen Presenting Cell Biology, a section of the journal Frontiers in Immunology
Edited by: Luis C. Anton, Consejo Superior de Investigaciones Científicas (CSIC), Spain
Reviewed by: Barbara Seliger, Martin Luther University of Halle-Wittenberg, Germany; David A. Scheinberg, Memorial Sloan Kettering Cancer Center, United States
Descrição: Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface. This allows CD8 T cells to identify pathological cells that are synthesizing abnormal proteins, such as cancers that are expressing mutated proteins. In order for many cancers to arise and progress, they need to evolve mechanisms to avoid elimination by CD8 T cells. MHC I molecules are not essential for cell survival and therefore one mechanism by which cancers can evade immune control is by losing MHC I antigen presentation machinery (APM). Not only will this impair the ability of natural immune responses to control cancers, but also frustrate immunotherapies that work by re-invigorating anti-tumor CD8 T cells, such as checkpoint blockade. Here we review the evidence that loss of MHC I antigen presentation is a frequent occurrence in many cancers. We discuss new insights into some common underlying mechanisms through which some cancers inactivate the MHC I pathway and consider some possible strategies to overcome this limitation in ways that could restore immune control of tumors and improve immunotherapy.
Editor: Switzerland: Frontiers Media S.A
Idioma: Inglês

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Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Dhatchinamoorthy, Karthik ; Colbert, Jeff D ; Rock, Kenneth L

Switzerland: Frontiers Media S.A

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