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Mycobacterium abscessus complex infections in humans

Lee, Meng-Rui ; Sheng, Wang-Huei ; Hung, Chien-Ching ; Yu, Chong-Jen ; Lee, Li-Na ; Hsueh, Po-Ren

Emerging infectious diseases, 2015-09, Vol.21 (9), p.1638-1646 [Peer Reviewed Journal]

U.S. National Center for Infectious Diseases

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Title:
Mycobacterium abscessus complex infections in humans
Author: Lee, Meng-Rui ; Sheng, Wang-Huei ; Hung, Chien-Ching ; Yu, Chong-Jen ; Lee, Li-Na ; Hsueh, Po-Ren
Subjects: Antibacterial agents ; Care and treatment ; Diagnosis ; Dosage and administration ; multidrug resistant ; Mycobacterial infections ; Mycobacterium abscessus ; Mycobacterium abscessus complex ; Mycobacterium bolletii ; Mycobacterium massiliense ; nontuberculous ; Risk factors
Is Part Of: Emerging infectious diseases, 2015-09, Vol.21 (9), p.1638-1646
Description: Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections. M. abscessus complex is differentiated into 3 subspecies: M. abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. abscessus subsp. bolletii. The 2 major subspecies, M. abscessus subsp. abscessus and M. abscessus subsp. massiliense, have different erm(41) gene patterns. This gene provides intrinsic resistance to macrolides, so the different patterns lead to different treatment outcomes. M. abscessus complex outbreaks associated with cosmetic procedures and nosocomial transmissions are not uncommon. Clarithromycin, amikacin, and cefoxitin are the current antimicrobial drugs of choice for treatment. However, new treatment regimens are urgently needed, as are rapid and inexpensive identification methods and measures to contain nosocomial transmission and outbreaks.
Publisher: U.S. National Center for Infectious Diseases
Language: English

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Mycobacterium abscessus complex infections in humans

Lee, Meng-Rui ; Sheng, Wang-Huei ; Hung, Chien-Ching ; Yu, Chong-Jen ; Lee, Li-Na ; Hsueh, Po-Ren

U.S. National Center for Infectious Diseases

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