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The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis

Gao, Qi ; Kou, Tingyan ; Zhuang, Bin ; Ren, Yangyang ; Dong, Xue ; Wang, Qiuzhen

Nutrients, 2018-10, Vol.10 (10), p.1395 [Periódico revisado por pares]

Switzerland: MDPI

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Título:
The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis
Autor: Gao, Qi ; Kou, Tingyan ; Zhuang, Bin ; Ren, Yangyang ; Dong, Xue ; Wang, Qiuzhen
Assuntos: Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; Child, Preschool ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Review ; Risk Factors ; serum 25(OH)D ; sleep ; Sleep - physiology ; sleep disorders ; sleep duration ; sleep quality ; Sleep Wake Disorders - blood ; Sleep Wake Disorders - etiology ; vitamin D ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - physiopathology ; Young Adult
É parte de: Nutrients, 2018-10, Vol.10 (10), p.1395
Notas: ObjectType-Article-2
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Descrição: Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included. By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72). Subgroup analysis showed that VDD also was associated with poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05), short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and sleepiness (OR: 1.36, 95% CI: 1.12, 1.65). Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep. This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.
Editor: Switzerland: MDPI
Idioma: Inglês

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The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis

Gao, Qi ; Kou, Tingyan ; Zhuang, Bin ; Ren, Yangyang ; Dong, Xue ; Wang, Qiuzhen

Switzerland: MDPI

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