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Hypotension prediction index guided goal-directed therapy to reduce postoperative acute kidney injury during major abdominal surgery: study protocol for a multicenter randomized controlled clinical trial

Ripollés-Melchor, Javier ; Carrasco-Sánchez, Laura ; Tomé-Roca, José L ; Aldecoa, César ; Zorrilla-Vaca, Andres ; Lorente-Olazábal, Juan V ; Colomina, María J ; Pérez, Ana ; Jiménez-López, Juan I ; Navarro-Pérez, Rosalía ; Abad-Gurumeta, Alfredo ; Monge-García, Manuel I

Current controlled trials in cardiovascular medicine, 2024-04, Vol.25 (1), p.288-288 [Periódico revisado por pares]

England: BioMed Central Ltd

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Hypotension prediction index guided goal-directed therapy to reduce postoperative acute kidney injury during major abdominal surgery: study protocol for a multicenter randomized controlled clinical trial
Autor: Ripollés-Melchor, Javier ; Carrasco-Sánchez, Laura ; Tomé-Roca, José L ; Aldecoa, César ; Zorrilla-Vaca, Andres ; Lorente-Olazábal, Juan V ; Colomina, María J ; Pérez, Ana ; Jiménez-López, Juan I ; Navarro-Pérez, Rosalía ; Abad-Gurumeta, Alfredo ; Monge-García, Manuel I
Assuntos: Abdomen ; Abdomen - surgery ; Abdominal surgery ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - etiology ; Acute Kidney Injury - prevention & control ; Acute Kidney Injury - therapy ; Acute renal failure ; Aged ; Algorithms ; Anesthesiology ; Blood pressure ; Clinical medicine ; Clinical trials ; Complications and side effects ; Early Goal-Directed Therapy ; Early oal-irected emodynamic therapy ; Elective Surgical Procedures ; Evaluation ; Female ; Fluid herapy ; Gastrointestinal surgery ; Health aspects ; Hemodynamic monitoring ; Hemodynamic onitoring ; Hemodynamic ptimization ; Hemodynamics ; Hospitals ; Humans ; Hypotension ; Hypotension - etiology ; Hypotension - prevention & control ; Informed consent ; Intervention ; Kidneys ; Major lective bdominal urgery ; Male ; Multicenter Studies as Topic ; Patients ; Postoperative Complications - etiology ; Postoperative Complications - prevention & control ; Postoperative omplications ; Prevention ; Randomized Controlled Trials as Topic ; Risk Factors ; Sensors ; Study Protocol ; Time Factors ; Treatment Outcome
É parte de: Current controlled trials in cardiovascular medicine, 2024-04, Vol.25 (1), p.288-288
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Descrição: Acute kidney injury (AKI) is a significant postoperative complication associated with increased mortality and hospital costs. Hemodynamic strategies, such as goal-directed therapy, might reduce AKI risk. Predicting and proactively managing intraoperative hypotension may be helpful. This trial aims to investigate if a preemptive hemodynamic strategy guided by the hypotension prediction index (HPI) can decrease the incidence of moderate-to-severe AKI within 30 days following major elective abdominal surgery. This is an open-label, controlled, multicenter, randomized clinical trial that involves daily patient follow-up until hospital discharge. Inclusion criteria are patients aged over 65 and/or categorized as ASA III or IV physical status, undergoing major elective abdominal surgery (general, urological, or gynecological procedures) via laparoscopic or open approach under general or combined anesthesia. In the intervention group, hemodynamic management will be based on the HPI and the advanced functional hemodynamic variables provided by the Hemosphere platform and the AcumenIQ® sensor (Edwards Lifesciences). The primary outcome is the incidence of moderate-to-severe AKI within 7 days post-surgery. Secondary outcomes include postoperative complications and 30-day mortality. This study explores the potential of HPI-guided hemodynamic management in reducing AKI after major elective abdominal surgery, with implications for postoperative outcomes and patient care. ClinicalTrials.gov NCT05569265. Registered on October 6, 2022.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Hypotension prediction index guided goal-directed therapy to reduce postoperative acute kidney injury during major abdominal surgery: study protocol for a multicenter randomized controlled clinical trial

Ripollés-Melchor, Javier ; Carrasco-Sánchez, Laura ; Tomé-Roca, José L ; Aldecoa, César ; Zorrilla-Vaca, Andres ; Lorente-Olazábal, Juan V ; Colomina, María J ; Pérez, Ana ; Jiménez-López, Juan I ; Navarro-Pérez, Rosalía ; Abad-Gurumeta, Alfredo ; Monge-García, Manuel I

England: BioMed Central Ltd

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