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Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development

Zhang, Ying ; Yu, Bing ; Qi, Qibin ; Azarbarzin, Ali ; Chen, Han ; Shah, Neomi A ; Ramos, Alberto R ; Zee, Phyllis C ; Cai, Jianwen ; Daviglus, Martha L ; Boerwinkle, Eric ; Kaplan, Robert ; Liu, Peter Y ; Redline, Susan ; Sofer, Tamar

Nature communications, 2024-02, Vol.15 (1), p.1845-16, Article 1845 [Periódico revisado por pares]

England: Nature Publishing Group

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Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development
Autor: Zhang, Ying ; Yu, Bing ; Qi, Qibin ; Azarbarzin, Ali ; Chen, Han ; Shah, Neomi A ; Ramos, Alberto R ; Zee, Phyllis C ; Cai, Jianwen ; Daviglus, Martha L ; Boerwinkle, Eric ; Kaplan, Robert ; Liu, Peter Y ; Redline, Susan ; Sofer, Tamar
Assuntos: Adults ; Aged ; Airway management ; Biomarkers ; Breathing ; Cardiovascular diseases ; Diabetes ; Diabetes Mellitus ; Health risks ; Humans ; Hypertension ; Hypertension - complications ; Male ; Metabolites ; Metabolomics ; Pregnanolone ; Principal components analysis ; Progesterone ; Regression Analysis ; Respiration ; Risk ; Risk Factors ; Serum levels ; Sleep ; Sleep Apnea Syndromes ; Sleep disorders ; Young Adult ; Young adults
É parte de: Nature communications, 2024-02, Vol.15 (1), p.1845-16, Article 1845
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply principal component analysis (PCA) to seven SDB-related measures. We estimate the associations of the top two SDB PCs with serum levels of 617 metabolites, in both single-metabolite analysis, and a joint penalized regression analysis. The discovery analysis includes 3299 individuals, with validation in a separate dataset of 1522 individuals. Five metabolite associations with SDB PCs are discovered and replicated. SDB PC1, characterized by frequent respiratory events common in older and male adults, is associated with pregnanolone and progesterone-related sulfated metabolites. SDB PC2, characterized by short respiratory event length and self-reported restless sleep, enriched in young adults, is associated with sphingomyelins. Metabolite risk scores (MRSs), representing metabolite signatures associated with the two SDB PCs, are associated with 6-year incident hypertension and diabetes. These MRSs have the potential to serve as biomarkers for SDB, guiding risk stratification and treatment decisions.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development

Zhang, Ying ; Yu, Bing ; Qi, Qibin ; Azarbarzin, Ali ; Chen, Han ; Shah, Neomi A ; Ramos, Alberto R ; Zee, Phyllis C ; Cai, Jianwen ; Daviglus, Martha L ; Boerwinkle, Eric ; Kaplan, Robert ; Liu, Peter Y ; Redline, Susan ; Sofer, Tamar

England: Nature Publishing Group

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