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Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity

Dahlet, Thomas ; Argüeso Lleida, Andrea ; Al Adhami, Hala ; Dumas, Michael ; Bender, Ambre ; Ngondo, Richard P ; Tanguy, Manon ; Vallet, Judith ; Auclair, Ghislain ; Bardet, Anaïs F ; Weber, Michael

Nature communications, 2020-06, Vol.11 (1), p.3153-3153, Article 3153 [Revista revisada por pares]

England: Nature Publishing Group

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Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity
Autor: Dahlet, Thomas ; Argüeso Lleida, Andrea ; Al Adhami, Hala ; Dumas, Michael ; Bender, Ambre ; Ngondo, Richard P ; Tanguy, Manon ; Vallet, Judith ; Auclair, Ghislain ; Bardet, Anaïs F ; Weber, Michael
Materias: Animals ; Deactivation ; Deoxyribonucleic acid ; DNA ; DNA (Cytosine-5-)-Methyltransferase 1 - genetics ; DNA (Cytosine-5-)-Methyltransferase 1 - metabolism ; DNA (Cytosine-5-)-Methyltransferases - genetics ; DNA (Cytosine-5-)-Methyltransferases - metabolism ; DNA methylation ; DNA Methylation - genetics ; DNA Methylation - physiology ; DNA Methyltransferase 3B ; DNMT1 protein ; Embryo, Mammalian - metabolism ; Embryonic Development - genetics ; Embryos ; Epigenomics ; Gene expression ; Gene Expression Regulation ; Genes ; Genome ; Genomes ; Implantation ; Inactivation ; Integrity ; Life Sciences ; Mice ; Transcriptome ; Transposons ; Vegetal Biology
Es parte de: Nature communications, 2020-06, Vol.11 (1), p.3153-3153, Article 3153
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descripción: Mouse embryos acquire global DNA methylation of their genome during implantation. However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been studied comprehensively. Here we systematically analyze the consequences of genetic inactivation of Dnmt1, Dnmt3a and Dnmt3b on the methylome and transcriptome of mouse embryos. We find a strict division of function between DNMT1, responsible for maintenance methylation, and DNMT3A/B, solely responsible for methylation acquisition in development. By analyzing severely hypomethylated embryos, we uncover multiple functions of DNA methylation that is used as a mechanism of repression for a panel of genes including not only imprinted and germline genes, but also lineage-committed genes and 2-cell genes. DNA methylation also suppresses multiple retrotransposons and illegitimate transcripts from cryptic promoters in transposons and gene bodies. Our work provides a thorough analysis of the roles of DNA methyltransferases and the importance of DNA methylation for transcriptome integrity in mammalian embryos.
Editor: England: Nature Publishing Group
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Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity

Dahlet, Thomas ; Argüeso Lleida, Andrea ; Al Adhami, Hala ; Dumas, Michael ; Bender, Ambre ; Ngondo, Richard P ; Tanguy, Manon ; Vallet, Judith ; Auclair, Ghislain ; Bardet, Anaïs F ; Weber, Michael

England: Nature Publishing Group

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