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The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

Oliveira, Rui C. ; Abrantes, Ana Margarida ; Tralhão, José Guilherme ; Botelho, Maria Filomena

Animal models and experimental medicine, 2020-03, Vol.3 (1), p.1-8 [Periódico revisado por pares]

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Título:
The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models
Autor: Oliveira, Rui C. ; Abrantes, Ana Margarida ; Tralhão, José Guilherme ; Botelho, Maria Filomena
Assuntos: Animal models ; Cancer ; Cancer research ; Cancer therapies ; Cell culture ; Cell cycle ; Colorectal cancer ; Colorectal carcinoma ; Deoxyribonucleic acid ; Disease ; DNA ; Genes ; Genomes ; Laboratories ; Medical prognosis ; Medical research ; Metastasis ; mouse model ; orthotopic model ; Physiology ; Review ; Therapeutic applications ; Transgenic animals ; Tumors
É parte de: Animal models and experimental medicine, 2020-03, Vol.3 (1), p.1-8
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models.
Editor: United States: John Wiley & Sons, Inc
Idioma: Inglês

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