Idioma:

Organic effects of associating paclitaxel with a lipid-based nanoparticle system on a nonhuman primate, Cebus apella

Feio, Danielle Cristinne Azevedo ; de Oliveira, Nayara Cristina Lima ; Pereira, Edmundo Luis Rodrigues ; Morikawa, Aleksandra Tiemi ; Muniz, José Augusto Pereira Carneiro ; Montenegro, Raquel Carvalho ; Alves, Ana Paula Negreiros Nunes ; de Lima, Patrícia Danielle Lima ; Maranhão, Raul Cavalcante ; Burbano, Rommel Rodríguez

International journal of nanomedicine, 2017-01, Vol.12, p.3827-3837 [Periódico revisado por pares]

New Zealand: Dove Medical Press Limited

Texto completo disponível

Citações Citado por

Enviar para

Título:
Organic effects of associating paclitaxel with a lipid-based nanoparticle system on a nonhuman primate, Cebus apella
Autor: Feio, Danielle Cristinne Azevedo ; de Oliveira, Nayara Cristina Lima ; Pereira, Edmundo Luis Rodrigues ; Morikawa, Aleksandra Tiemi ; Muniz, José Augusto Pereira Carneiro ; Montenegro, Raquel Carvalho ; Alves, Ana Paula Negreiros Nunes ; de Lima, Patrícia Danielle Lima ; Maranhão, Raul Cavalcante ; Burbano, Rommel Rodríguez
Assuntos: Analysis ; Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - pharmacology ; Biodiversity ; Cancer therapies ; Cebus ; Chemotherapy ; Cholesterol ; Cholesterol - chemistry ; Complications and side effects ; Dosage and administration ; Dose-Response Relationship, Drug ; Drug Carriers - administration & dosage ; Drug Carriers - adverse effects ; Drug Carriers - pharmacology ; Drug delivery systems ; Drugs ; Emulsions - administration & dosage ; Emulsions - chemistry ; Health sciences ; Laboratories ; Lipids - chemistry ; Male ; Medical research ; Monkeys & apes ; Nanoemulsions ; Nanoparticles ; Nanoparticles - administration & dosage ; Nanoparticles - adverse effects ; Nanoparticles. LDE. Pacliatxel. Toxicity. Cebus apella ; Neoplasms - drug therapy ; Original Research ; Paclitaxel ; Paclitaxel - administration & dosage ; Paclitaxel - adverse effects ; Paclitaxel - pharmacology ; Physiological aspects ; Properties ; Tissue Distribution ; Toxicity Tests, Chronic - methods
É parte de: International journal of nanomedicine, 2017-01, Vol.12, p.3827-3837
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Lipid-based nanoparticle systems have been used as vehicles for chemotherapeutic agents in experimental cancer treatments. Those systems have generally been credited with attenuating the severe toxicity of chemotherapeutic agents. This study aimed to investigate the effects of associating paclitaxel (PTX) with a lipid-based nanoparticle system on a nonhuman primate, , documenting the toxicity as measured by serum biochemistry, which is a detailed analysis of blood and tissue. Eighteen were studied: three animals were treated with cholesterol-rich nanoemulsion (LDE) only, without PTX, administered intravenously every 3 weeks, during six treatment cycles; six animals were treated with PTX associated with LDE at the same administration scheme, three with lower (175 mg/m ) and three with higher (250 mg/m ) PTX doses; and six animals were treated with commercial PTX, three with the lower and three with the higher doses. In the LDE-PTX group, no clinical toxicity appeared, and the weight-food consumption curve was similar to that of the controls. Two animals treated with commercial PTX presented weight loss, nausea and vomiting, diarrhea, skin flaking, 70% loss of body hair, and decreased physical activity. The use of LDE as a carrier at both lower and higher doses reduced the toxicity of the drug in this species, which is closely related to human subjects. This was observed not only by clinical, biochemical, and hematological profiles but also by the histopathological analysis. The results of this study support the assumption that lipid-based nanoparticle systems used as drug carriers can serve as valuable tools to decrease the toxicity and increase the safety of chemotherapeutic agents.
Editor: New Zealand: Dove Medical Press Limited
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 2

Realização: Logos de Redes Sociais:

Organic effects of associating paclitaxel with a lipid-based nanoparticle system on a nonhuman primate, Cebus apella

New Zealand: Dove Medical Press Limited

Buscando em bases de dados remotas. Favor aguardar.