Idioma:

Cheminformatics-Based Design and Synthesis of Hydroxyapatite/Collagen Nanocomposites for Biomedical Applications

Aaddouz, Mohamed ; Azzaoui, Khalil ; Sabbahi, Rachid ; Youssoufi, Moulay Hfid ; Yahyaoui, Meryem Idrissi ; Asehraou, Abdeslam ; El Miz, Mohamed ; Hammouti, Belkheir ; Shityakov, Sergey ; Siaj, Mohamed ; Mejdoubi, Elmiloud

Polymers, 2023-12, Vol.16 (1), p.85 [Periódico revisado por pares]

Switzerland: MDPI AG

Texto completo disponível

Citações Citado por

Enviar para

Título:
Cheminformatics-Based Design and Synthesis of Hydroxyapatite/Collagen Nanocomposites for Biomedical Applications
Autor: Aaddouz, Mohamed ; Azzaoui, Khalil ; Sabbahi, Rachid ; Youssoufi, Moulay Hfid ; Yahyaoui, Meryem Idrissi ; Asehraou, Abdeslam ; El Miz, Mohamed ; Hammouti, Belkheir ; Shityakov, Sergey ; Siaj, Mohamed ; Mejdoubi, Elmiloud
Assuntos: antimicrobial ; Antimicrobial agents ; Bioavailability ; Biocompatibility ; biocomposite ; Biological products ; Biological properties ; Biomedical engineering ; Biomedical materials ; Bones ; co-precipitation ; Collagen ; Dental implants ; Dental materials ; Design optimization ; Design parameters ; Diffraction ; Drug delivery systems ; Drugs ; Fourier transforms ; Hydroxyapatite ; Implant dentures ; In vivo methods and tests ; Infrared analysis ; Infrared reflection ; Infrared spectroscopy ; Mechanical properties ; Methods ; Nanocomposites ; Nitrates ; Orthopedics ; Physiological aspects ; Radiation ; Scanning electron microscopy ; Spectrum analysis ; Synthesis ; Technology application ; Thermogravimetric analysis ; Tissue engineering ; Transplants & implants ; Vehicles ; Wound healing ; X-ray spectroscopy ; X-rays
É parte de: Polymers, 2023-12, Vol.16 (1), p.85
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: This paper presents a novel cheminformatics approach for the design and synthesis of hydroxyapatite/collagen nanocomposites, which have potential biomedical applications in tissue engineering, drug delivery, and orthopedic and dental implants. The nanocomposites are synthesized by the co-precipitation method with different ratios of hydroxyapatite and collagen. Their mechanical, biological, and degradation properties are analyzed using various experimental and computational techniques. Attenuated total reflection-Fourier-transform infrared spectroscopy, thermogravimetric analysis, and X-ray diffraction unveil the low crystallinity and nanoscale particle size of hydroxyapatite (22.62 nm) and hydroxyapatite/collagen composites (14.81 nm). These findings are substantiated by scanning electron microscopy with energy-dispersive X-ray spectroscopy, confirming the Ca/P ratio between 1.65 and 1.53 and attesting to the formation of non-stoichiometric apatites in all samples, further validated by molecular simulation. The antimicrobial activity of the nanocomposites is evaluated in vitro against several bacterial and fungal strains, demonstrating their medical potential. Additionally, in silico analyses are performed to predict the absorption, distribution, metabolism, and excretion properties and the bioavailability of the collagen samples. This study paves the way for the development of novel biomaterials using chemoinformatics tools and methods, facilitating the optimization of design and synthesis parameters, as well as the prediction of biological outcomes. Future research directions should encompass the investigation of in vivo biocompatibility and bioactivity of the nanocomposites, while exploring further applications and functionalities of these innovative materials.
Editor: Switzerland: MDPI AG
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 4 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Cheminformatics-Based Design and Synthesis of Hydroxyapatite/Collagen Nanocomposites for Biomedical Applications

Aaddouz, Mohamed ; Azzaoui, Khalil ; Sabbahi, Rachid ; Youssoufi, Moulay Hfid ; Yahyaoui, Meryem Idrissi ; Asehraou, Abdeslam ; El Miz, Mohamed ; Hammouti, Belkheir ; Shityakov, Sergey ; Siaj, Mohamed ; Mejdoubi, Elmiloud

Switzerland: MDPI AG

Buscando em bases de dados remotas. Favor aguardar.