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Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection

Zuo, Tao ; Wong, Sunny H ; Cheung, Chun Pan ; Lam, Kelvin ; Lui, Rashid ; Cheung, Kitty ; Zhang, Fen ; Tang, Whitney ; Ching, Jessica Y L ; Wu, Justin C Y ; Chan, Paul K S ; Sung, Joseph J Y ; Yu, Jun ; Chan, Francis K L ; Ng, Siew C

Nature communications, 2018-09, Vol.9 (1), p.3663-11, Article 3663 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection
Autor: Zuo, Tao ; Wong, Sunny H ; Cheung, Chun Pan ; Lam, Kelvin ; Lui, Rashid ; Cheung, Kitty ; Zhang, Fen ; Tang, Whitney ; Ching, Jessica Y L ; Wu, Justin C Y ; Chan, Paul K S ; Sung, Joseph J Y ; Yu, Jun ; Chan, Francis K L ; Ng, Siew C
Assuntos: Abundance ; Adult ; Animals ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Aspergillus ; Bacteria ; Candida albicans ; Clostridium difficile ; Clostridium Infections - therapy ; Colonization ; Dysbacteriosis ; Dysbiosis - complications ; Effectiveness ; Fecal Microbiota Transplantation ; Fecal microflora ; Feces - microbiology ; Female ; Fungi ; Fungicides ; Gastrointestinal Microbiome ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Microbiota ; Multivariate Analysis ; Recurrence ; Recurrent infection ; Relative abundance ; RNA, Ribosomal, 16S - genetics ; Saccharomyces ; Transplantation
É parte de: Nature communications, 2018-09, Vol.9 (1), p.3663-11, Article 3663
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Fecal microbiota transplantation (FMT) is effective in treating recurrent Clostridium difficile infection (CDI). Bacterial colonization in recipients after FMT has been studied, but little is known about the role of the gut fungal community, or mycobiota. Here, we show evidence of gut fungal dysbiosis in CDI, and that donor-derived fungal colonization in recipients is associated with FMT response. CDI is accompanied by over-representation of Candida albicans and decreased fungal diversity, richness, and evenness. Cure after FMT is associated with increased colonization of donor-derived fungal taxa in recipients. Recipients of successful FMT ("responders") display, after FMT, a high relative abundance of Saccharomyces and Aspergillus, whereas "nonresponders" and individuals treated with antibiotics display a dominant presence of Candida. High abundance of C. albicans in donor stool also correlates with reduced FMT efficacy. Furthermore, C. albicans reduces FMT efficacy in a mouse model of CDI, while antifungal treatment reestablishes its efficacy, supporting a potential causal relationship between gut fungal dysbiosis and FMT outcome.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection

Zuo, Tao ; Wong, Sunny H ; Cheung, Chun Pan ; Lam, Kelvin ; Lui, Rashid ; Cheung, Kitty ; Zhang, Fen ; Tang, Whitney ; Ching, Jessica Y L ; Wu, Justin C Y ; Chan, Paul K S ; Sung, Joseph J Y ; Yu, Jun ; Chan, Francis K L ; Ng, Siew C

England: Nature Publishing Group

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