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Winter is coming: the future of cryopreservation

Bojic, Sanja ; Murray, Alex ; Bentley, Barry L ; Spindler, Ralf ; Pawlik, Piotr ; Cordeiro, José L ; Bauer, Roman ; de Magalhães, João Pedro

BMC biology, 2021-03, Vol.19 (1), p.56-56, Article 56 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Winter is coming: the future of cryopreservation
Autor: Bojic, Sanja ; Murray, Alex ; Bentley, Barry L ; Spindler, Ralf ; Pawlik, Piotr ; Cordeiro, José L ; Bauer, Roman ; de Magalhães, João Pedro
Assuntos: Biocompatibility ; Biological materials ; Biostasis ; Cooling ; Cryobiology ; Cryopreservation ; Cryopreservation of organs, tissues, etc ; Cryoprotectors ; Donation of organs, tissues, etc ; Drug discovery ; Forecasts and trends ; Freezing ; Glycerol ; Ice formation ; Low temperature ; Medicine ; Methods ; Organ banking ; Organs ; Preservatives ; R&D ; Regenerative medicine ; Research & development ; Review ; Tissue engineering ; Toxicity ; Transplantation ; Transplantation of organs, tissues, etc ; Vitrification
É parte de: BMC biology, 2021-03, Vol.19 (1), p.56-56, Article 56
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The preservative effects of low temperature on biological materials have been long recognised, and cryopreservation is now widely used in biomedicine, including in organ transplantation, regenerative medicine and drug discovery. The lack of organs for transplantation constitutes a major medical challenge, stemming largely from the inability to preserve donated organs until a suitable recipient is found. Here, we review the latest cryopreservation methods and applications. We describe the main challenges-scaling up to large volumes and complex tissues, preventing ice formation and mitigating cryoprotectant toxicity-discuss advantages and disadvantages of current methods and outline prospects for the future of the field.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Winter is coming: the future of cryopreservation

Bojic, Sanja ; Murray, Alex ; Bentley, Barry L ; Spindler, Ralf ; Pawlik, Piotr ; Cordeiro, José L ; Bauer, Roman ; de Magalhães, João Pedro

England: BioMed Central Ltd

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