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Single cell transcriptome atlas of the Drosophila larval brain

Brunet Avalos, Clarisse ; Maier, G Larisa ; Bruggmann, Rémy ; Sprecher, Simon G

eLife, 2019-11, Vol.8 [Periódico revisado por pares]

England: eLife Science Publications, Ltd

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Título:
Single cell transcriptome atlas of the Drosophila larval brain
Autor: Brunet Avalos, Clarisse ; Maier, G Larisa ; Bruggmann, Rémy ; Sprecher, Simon G
Assuntos: Animals ; Brain ; Brain - cytology ; Brain - growth & development ; cell diversity ; Datasets ; Dissection ; Drosophila ; Drosophila - growth & development ; Gene expression ; Genes ; Genetic diversity ; Genomics ; Glial stem cells ; Insects ; larva ; Larva - growth & development ; Nervous system ; Neural stem cells ; Neuronal-glial interactions ; Neurons ; Neuroscience ; Nutrition ; Peptides ; single cell transcriptome ; Single-Cell Analysis ; Starvation ; Transcription ; Transcriptome
É parte de: eLife, 2019-11, Vol.8
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Cell diversity of the brain and how it is affected by starvation, remains largely unknown. Here, we introduce a single cell transcriptome atlas of the entire first instar larval brain. We first assigned cell-type identity based on known marker genes, distinguishing five major groups: neural progenitors, differentiated neurons, glia, undifferentiated neurons and non-neural cells. All major classes were further subdivided into multiple subtypes, revealing biological features of various cell-types. We further assessed transcriptional changes in response to starvation at the single-cell level. While after starvation the composition of the brain remains unaffected, transcriptional profile of several cell clusters changed. Intriguingly, different cell-types show very distinct responses to starvation, suggesting the presence of cell-specific programs for nutrition availability. Establishing a single-cell transcriptome atlas of the larval brain provides a powerful tool to explore cell diversity and assess genetic profiles from developmental, functional and behavioral perspectives.
Editor: England: eLife Science Publications, Ltd
Idioma: Inglês

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Single cell transcriptome atlas of the Drosophila larval brain

Brunet Avalos, Clarisse ; Maier, G Larisa ; Bruggmann, Rémy ; Sprecher, Simon G

England: eLife Science Publications, Ltd

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