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Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds

Caruso, Daniel J ; Palombo, Enzo A ; Moulton, Simon E ; Zaferanloo, Bita

Microorganisms (Basel), 2022-10, Vol.10 (10), p.1990 [Peer Reviewed Journal]

Basel: MDPI AG

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Title:
Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds
Author: Caruso, Daniel J ; Palombo, Enzo A ; Moulton, Simon E ; Zaferanloo, Bita
Subjects: Aliphatic compounds ; Anti-infective agents ; antibiofilm ; Antibiotics ; antimicrobial ; Antimicrobial agents ; Antimicrobial resistance ; Automation ; Awards & honors ; Bioactive compounds ; Biological activity ; Chemical compounds ; Chemical properties ; Coronaviruses ; Drug resistance ; Drug resistance in microorganisms ; Drugs ; Endophytes ; Fungi ; Host plants ; Infectious diseases ; Marine plants ; Medicine ; Metabolites ; Microorganisms ; Motivation ; Natural products ; novel ; Penicillin ; Peptides ; Pharmaceutical industry ; Pharmaceutical research ; Phenols ; Plant tissues ; Polyketides ; Review ; Success ; Symbiosis ; Terpenes
Is Part Of: Microorganisms (Basel), 2022-10, Vol.10 (10), p.1990
Notes: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Description: Over the last few decades, many of the existing drugs used to treat infectious diseases have become increasingly ineffective due to the global emergence of antimicrobial resistance (AMR). As such, there is a constant demand to find new, effective compounds that could help to alleviate some of this pressure. Endophytic fungi have captured the attention of many researchers in this field, as they have displayed a vast ability to produce novel bioactive compounds, many of which possess wide-ranging antimicrobial activities. However, while highly promising, research in this area is still in its infancy. Endophytes inhabit the healthy tissues of plants asymptomatically, resulting in a mutualistic symbiosis in which the endophytes produce a plethora of bioactive compounds that support the fitness of the host plant. These compounds display great chemical diversity, representing structural groups, such as aliphatic compounds, alkaloids, peptides, phenolics, polyketides and terpenoids. In this review, the significant antimicrobial potential of endophytic fungi is detailed, highlighting their ability to produce novel and diverse antimicrobial compounds active against human, plant and marine pathogens. In doing so, it also highlights the significant contributions that endophytic fungi can make in our battle against AMR, thus providing the motivation to increase efforts in the search for new and effective antimicrobial drugs.
Publisher: Basel: MDPI AG
Language: English

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Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds

Caruso, Daniel J ; Palombo, Enzo A ; Moulton, Simon E ; Zaferanloo, Bita

Basel: MDPI AG

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