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Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair
Song
,
Rui
; Zhang, Lubo
International journal of molecular sciences, 2020-11, Vol.21 (22), p.8610
[Periódico revisado por pares]
Switzerland: MDPI AG
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Título:
Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair
Autor:
Song
,
Rui
;
Zhang, Lubo
Assuntos:
Animals
;
Apoptosis
;
cardiac development
;
Cardiomyocytes
;
Cardiovascular disease
;
Cardiovascular diseases
;
Cardiovascular Diseases - metabolism
;
Cardiovascular Diseases - pathology
;
Cardiovascular system
;
Cell adhesion & migration
;
Cellular structure
;
Chemokines
;
Drug development
;
Epigenesis, Genetic
;
Epigenetics
;
Extracellular matrix
;
Extracellular Matrix - metabolism
;
Extracellular Matrix - pathology
;
Fibroblasts
;
Gene expression
;
Glycoproteins
;
Growth factors
;
Heart
;
Heart attacks
;
Humans
;
Hyaluronic acid
;
Ischemia
;
Metabolism
;
Mutation
;
Myocardium - metabolism
;
Myocardium - pathology
;
Proteins
;
regeneration
;
remodeling
;
Review
;
Signal transduction
;
Smooth muscle
;
Structure-function relationships
É parte de:
International journal of molecular sciences, 2020-11, Vol.21 (22), p.8610
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição:
The extracellular matrix (ECM) is the non-cellular component in the cardiac microenvironment, and serves essential structural and regulatory roles in establishing and maintaining tissue architecture and cellular function. The patterns of molecular and biochemical ECM alterations in developing and adult hearts depend on the underlying injury type. In addition to exploring how the ECM regulates heart structure and function in heart development and repair, this review conducts an inclusive discussion of recent developments in the role, function, and epigenetic guidelines of the ECM. Moreover, it contributes to the development of new therapeutics for cardiovascular disease.
Editor:
Switzerland: MDPI AG
Idioma:
Inglês
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View this record in MEDLINE/PubMed
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