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Quasispecies composition and evolution of a typical Zika virus clinical isolate from Suriname

van Boheemen, Sander ; Tas, Ali ; Anvar, S Yahya ; van Grootveld, Rebecca ; Albulescu, Irina C ; Bauer, Martijn P ; Feltkamp, Mariet C ; Bredenbeek, Peter J ; van Hemert, Martijn J

Scientific reports, 2017-05, Vol.7 (1), p.2368-7, Article 2368 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Quasispecies composition and evolution of a typical Zika virus clinical isolate from Suriname
Autor: van Boheemen, Sander ; Tas, Ali ; Anvar, S Yahya ; van Grootveld, Rebecca ; Albulescu, Irina C ; Bauer, Martijn P ; Feltkamp, Mariet C ; Bredenbeek, Peter J ; van Hemert, Martijn J
Assuntos: Adult ; Americas - epidemiology ; Animals ; Cell culture ; Cell surface ; Cercopithecus aethiops ; E protein ; Exanthema ; Female ; Fever ; Flavivirus ; Genome, Viral - genetics ; Genomes ; Headache ; Heparan sulfate ; Humans ; Mutation ; Nucleotide sequence ; Phylogeny ; Public health ; Quasispecies ; Sulfate ; Suriname ; Travel ; Vero Cells ; Viral Envelope Proteins - genetics ; Viral Nonstructural Proteins - genetics ; Zika virus ; Zika Virus - classification ; Zika Virus - genetics ; Zika Virus - physiology ; Zika Virus Infection - diagnosis ; Zika Virus Infection - epidemiology ; Zika Virus Infection - virology
É parte de: Scientific reports, 2017-05, Vol.7 (1), p.2368-7, Article 2368
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SourceType-Scholarly Journals-1
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Descrição: The arthropod-borne Zika virus (ZIKV) is currently causing a major international public health threat in the Americas. This study describes the isolation of ZIKV from the plasma of a 29-year-old female traveler that developed typical symptoms, like rash, fever and headache upon return from Suriname. The complete genome sequence including the 5' and 3' untranslated regions was determined and phylogenetic analysis showed the isolate clustering within the Asian lineage, close to other viruses that have recently been isolated in the Americas. In addition, the viral quasispecies composition was analyzed by single molecule real time sequencing, which suggested a mutation frequency of 1.4 × 10 for this ZIKV isolate. Continued passaging of the virus in cell culture led to the selection of variants with mutations in NS1 and the E protein. The latter might influence virus binding to cell surface heparan sulfate.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Quasispecies composition and evolution of a typical Zika virus clinical isolate from Suriname

van Boheemen, Sander ; Tas, Ali ; Anvar, S Yahya ; van Grootveld, Rebecca ; Albulescu, Irina C ; Bauer, Martijn P ; Feltkamp, Mariet C ; Bredenbeek, Peter J ; van Hemert, Martijn J

England: Nature Publishing Group

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