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High-Throughput UV Photoionization and Fragmentation of Neutral Biomolecules as a Structural Fingerprint

Wang, Siwen ; Dauletyarov, Yerbolat ; Horke, Daniel A

Molecules (Basel, Switzerland), 2023-06, Vol.28 (13), p.5058 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
High-Throughput UV Photoionization and Fragmentation of Neutral Biomolecules as a Structural Fingerprint
Autor: Wang, Siwen ; Dauletyarov, Yerbolat ; Horke, Daniel A
Assuntos: Acetaminophen ; Analgesics ; Biochemistry ; Biomolecules ; Biotechnology ; Experiments ; femtosecond ionization ; Fragmentation ; Ionization ; Ions ; Isomers ; Laser applications ; laser-based thermal desorption ; Lasers ; Lasers in biochemistry ; Mass spectra ; Mass Spectrometry ; Mass spectroscopy ; multiphoton ionization ; Paracetamol ; Phenylglycine ; photofragmentation ; Photoionization ; Wavelengths
É parte de: Molecules (Basel, Switzerland), 2023-06, Vol.28 (13), p.5058
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: We present UV photofragmentation studies of the structural isomers paracetamol, 3-Pyridinepropionic acid (3-PPIA) and (R)-(-)-2-Phenylglycine. In particular, we utilized a new laser-based thermal desorption source in combination with femtosecond multiphoton ionization at 343 nm and 257 nm. The continuous nature of our molecule source, combined with the 50 kHz repetition rate of the laser, allowed us to perform these experiments at high throughput. In particular, we present detailed laser intensity dependence studies at both wavelengths, producing 2D mass spectra with highly differential information about the underlying fragmentation processes. We show that UV photofragmentation produces highly isomer-specific mass spectra, and assign all major fragmentation pathways observed. The intensity-dependence measurements, furthermore, allowed us to evaluate the appearance intensities for each fragmentation channel, which helped to distinguish competing from consecutive fragmentation pathways.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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High-Throughput UV Photoionization and Fragmentation of Neutral Biomolecules as a Structural Fingerprint

Wang, Siwen ; Dauletyarov, Yerbolat ; Horke, Daniel A

Switzerland: MDPI AG

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