skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Age-Related Metabolic Pathways Changes in Dental Follicles: A Pilot Study

Bastos, Victor Coutinho ; Vitório, Jéssica Gardone ; Martins-Chaves, Roberta Rayra ; Leite-Lima, Flávia ; Lebron, Yuri Abner Rocha ; Moreira, Victor Rezende ; Duarte-Andrade, Filipe Fideles ; Pereira, Thaís Dos Santos Fontes ; Santos, Lucilaine Valéria de Souza ; Lange, Liséte Celina ; de Macedo, Adriana Nori ; Canuto, Gisele André Baptista ; Gomes, Carolina Cavaliéri ; Gomez, Ricardo Santiago

Frontiers in oral health, 2021-06, Vol.2, p.677731-677731 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

Texto completo disponível

Citações Citado por
  • Título:
    Age-Related Metabolic Pathways Changes in Dental Follicles: A Pilot Study
  • Autor: Bastos, Victor Coutinho ; Vitório, Jéssica Gardone ; Martins-Chaves, Roberta Rayra ; Leite-Lima, Flávia ; Lebron, Yuri Abner Rocha ; Moreira, Victor Rezende ; Duarte-Andrade, Filipe Fideles ; Pereira, Thaís Dos Santos Fontes ; Santos, Lucilaine Valéria de Souza ; Lange, Liséte Celina ; de Macedo, Adriana Nori ; Canuto, Gisele André Baptista ; Gomes, Carolina Cavaliéri ; Gomez, Ricardo Santiago
  • Assuntos: aging ; dental follicle ; dental sac ; developmental biology ; Oral Health ; oral pathology ; untargeted metabolomics
  • É parte de: Frontiers in oral health, 2021-06, Vol.2, p.677731-677731
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Reviewed by: Elena Riet Correa Rivero, Federal University of Santa Catarina, Brazil; Rogelio González-González, Juárez University of the State of Durango, Mexico; Celeste Sanchez-Romero, University of the Republic, Uruguay
    This article was submitted to Oral Cancers, a section of the journal Frontiers in Oral Health
    Edited by: Eliete Neves Da Silva Guerra, University of Brasilia, Brazil
    These authors have contributed equally to this work and share senior authorship
  • Descrição: Aging is not a matter of choice; it is our fate. The "time-dependent functional decline that affects most living organisms" is coupled with several alterations in cellular processes, such as cell senescence, epigenetic alterations, genomic instability, stem cell exhaustion, among others. Age-related morphological changes in dental follicles have been investigated for decades, mainly motivated by the fact that cysts and tumors may arise in association with unerupted and/or impacted teeth. The more we understand the physiology of dental follicles, the more we are able to contextualize biological events that can be associated with the occurrence of odontogenic lesions, whose incidence increases with age. Thus, our objective was to assess age-related changes in metabolic pathways of dental follicles associated with unerupted/impacted mandibular third molars from young and adult individuals. For this purpose, a convenience sample of formalin-fixed paraffin-embedded (FFPE) dental follicles from young (<16 y.o., = 13) and adult (>26 y.o., = 7) individuals was selected. Samples were analyzed by high-performance liquid chromatography-mass spectrometry (HPLC-MS)-based untargeted metabolomics. Multivariate and univariate analyses were conducted, and the prediction of altered pathways was performed by and Gene Set Enrichment Analysis (GSEA) approaches. Dental follicles from young and older individuals showed differences in pathways related to C21-steroid hormone biosynthesis, bile acid biosynthesis, galactose metabolism, androgen and estrogen biosynthesis, starch and sucrose metabolism, and lipoate metabolism. We conclude that metabolic pathways differences related to aging were observed between dental follicles from young and adult individuals. Our findings support that similar to other human tissues, dental follicles associated with unerupted tooth show alterations at a metabolic level with aging, which can pave the way for further studies on oral pathology, oral biology, and physiology.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.