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Nephroprotective effect of exercise training in cisplatin-induced renal damage in mice: influence of training protocol

Almeida, A.A ; Correia, T.M.L ; Pires, R.A ; da Silva, D.A ; Coqueiro, R.S ; Machado, M ; de Magalhaes, A.C.M ; Queiroz, R.F ; Soares, T.J ; Pereira, R

Brazilian journal of medical and biological research, 2022-01, Vol.55 (1), p.1-e12116 [Periódico revisado por pares]

Ribeirao Preto: Associacao Brasileira de Divulgacao Cientifica (ABDC)

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Título:
Nephroprotective effect of exercise training in cisplatin-induced renal damage in mice: influence of training protocol
Autor: Almeida, A.A ; Correia, T.M.L ; Pires, R.A ; da Silva, D.A ; Coqueiro, R.S ; Machado, M ; de Magalhaes, A.C.M ; Queiroz, R.F ; Soares, T.J ; Pereira, R
Assuntos: Adaptation ; Antioxidants ; Apoptosis ; BIOLOGY ; Body composition ; Chemotherapy ; Cisplatin ; Complications and side effects ; Drugs ; Enzymatic activity ; Epithelium ; Exercise intensity ; Exercise therapy ; Fitness training programs ; Gene expression ; Glutathione peroxidase ; Health aspects ; Inflammation ; Kidney diseases ; Kidneys ; Lipid peroxidation ; MEDICINE, RESEARCH & EXPERIMENTAL ; Nephrons ; Nephroprotection ; Nephrotoxicity ; NF-κB protein ; NRF2 protein ; Oxidative stress ; Physical exercise ; Physical training ; Prevention ; Redox balance ; Risk factors ; Swimming ; Testing
É parte de: Brazilian journal of medical and biological research, 2022-01, Vol.55 (1), p.1-e12116
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Cisplatin is an effective antineoplastic agent, but its use is limited by its nephrotoxicity caused by the oxidative stress in tubular epithelium of nephrons. On the other hand, regular exercise provides beneficial adaptations in different tissues and organs. As with many drugs, dosing is extremely important to get the beneficial effects of exercise. Thus, we aimed to investigate the influence of exercise intensity and frequency on cisplatin-induced (20 mg/kg) renal damage in mice. Forty male Swiss mice were divided into five experimental groups (n=8 per group): 1) sedentary; 2) low-intensity forced swimming, three times per week; 3) high-intensity forced swimming, three times per week; 4) low-intensity forced swimming, five times per week; and 5) high-intensity forced swimming, five times per week. Body composition, renal structure, functional indicators (plasma urea), lipid peroxidation, antioxidant enzyme activity, expression of genes related to antioxidant defense, and inflammatory and apoptotic pathways were evaluated. Comparisons considered exercise intensity and frequency. High lipid peroxidation was observed in the sedentary group compared with trained mice, regardless of exercise intensity and frequency. Groups that trained three times per week showed more benefits, as reduced tubular necrosis, plasma urea, expression of CASP3 and Rela (NFkB subunit- p65) genes, and increased total glutathione peroxidase activity. No significant difference in Nfe2l2 (Nrf2) gene expression was observed between groups. Eight weeks of regular exercise training promoted nephroprotection against cisplatin-mediated oxidative injury. Exercise frequency was critical for nephroprotection. Key words: Nephrotoxicity; Physical exercise; Nephroprotection; Redox balance; Swimming
Editor: Ribeirao Preto: Associacao Brasileira de Divulgacao Cientifica (ABDC)
Idioma: Inglês;Português

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Nephroprotective effect of exercise training in cisplatin-induced renal damage in mice: influence of training protocol

Almeida, A.A ; Correia, T.M.L ; Pires, R.A ; da Silva, D.A ; Coqueiro, R.S ; Machado, M ; de Magalhaes, A.C.M ; Queiroz, R.F ; Soares, T.J ; Pereira, R

Ribeirao Preto: Associacao Brasileira de Divulgacao Cientifica (ABDC)

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