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Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats

Seara, F A C ; Araujo, I G ; Império, G E ; Marassi, M P ; Silva, A C M ; Mecawi, A S ; Reis, L C ; Olivares, E L

Brazilian journal of medical and biological research, 2019-01, Vol.52 (10), p.e8491-e8491 [Periódico revisado por pares]

Brazil: Associacao Brasileira de Divulgacao Cientifica (ABDC)

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Título:
Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats
Autor: Seara, F A C ; Araujo, I G ; Império, G E ; Marassi, M P ; Silva, A C M ; Mecawi, A S ; Reis, L C ; Olivares, E L
Assuntos: Adipose tissue ; Adipose tissue (brown) ; Adipose Tissue, Brown - drug effects ; Adipose Tissue, Brown - metabolism ; Adipose tissues ; Adrenergic antagonists ; Adrenergic beta-Antagonists - administration & dosage ; Animals ; Attention deficit hyperactivity disorder ; Beta-blocker ; BIOLOGY ; Cardiac function ; Cardiovascular system ; Deiodinase ; Disease Models, Animal ; Drinking water ; Echocardiography ; EDTA ; Ethylenediaminetetraacetic acid ; Health ; Heart ; Heart attack ; Heart attacks ; Hormones ; Hyperactivity ; Hypothyroidism ; Iodide peroxidase ; Iodide Peroxidase - drug effects ; Iodide Peroxidase - metabolism ; Iodothyronine Deiodinase Type II ; Male ; MEDICINE, RESEARCH & EXPERIMENTAL ; Menopause ; Myocardial infarction ; Myocardial Infarction - metabolism ; Occlusion ; Propranolol ; Propranolol - administration & dosage ; Propranolol hydrochloride ; Rats ; Rats, Wistar ; Surgery ; Thyroid gland ; Thyroid hormone ; Thyroid hormones ; Thyroxine ; Thyroxine - blood ; Thyroxine - drug effects ; Triiodothyronine ; Triiodothyronine - blood ; Triiodothyronine - drug effects ; Water
É parte de: Brazilian journal of medical and biological research, 2019-01, Vol.52 (10), p.e8491-e8491
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
These authors contributed equally to this work.
Descrição: Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which would then constitute a possible target for β-adrenergic blocking agents in a myocardial infarction (MI) model induced by left coronary occlusion in rats. Despite a sustained and dramatic fall in serum T4 concentrations (60-70%), the serum T3 concentration fell only transiently in the first week post-infarction (53%) and returned to control levels at 8 and 12 weeks after surgery compared to the Sham group (P<0.05). Brown adipose tissue (BAT) D2 activity (fmol T4·min-1·mg ptn-1) was significantly increased by approximately 77% in the 8th week and approximately 100% in the 12th week in the MI group compared to that of the Sham group (P<0.05). Beta-blocker treatment (0.5 g/L propranolol given in the drinking water) maintained a low T3 state in MI animals, dampening both BAT D2 activity (44% reduction) and serum T3 (66% reduction in serum T3) compared to that of the non-treated MI group 12 weeks after surgery (P<0.05). Propranolol improved cardiac function (assessed by echocardiogram) in the MI group compared to the non-treated MI group by 40 and 57%, 1 and 12 weeks after treatment, respectively (P<0.05). Our data suggested that the beta-adrenergic pathway may contribute to BAT D2 hyperactivity and T3 normalization after MI in rats. Propranolol treatment maintained low T3 state and improved cardiac function additionally.
Editor: Brazil: Associacao Brasileira de Divulgacao Cientifica (ABDC)
Idioma: Inglês;Português

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Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats

Seara, F A C ; Araujo, I G ; Império, G E ; Marassi, M P ; Silva, A C M ; Mecawi, A S ; Reis, L C ; Olivares, E L

Brazil: Associacao Brasileira de Divulgacao Cientifica (ABDC)

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