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Distribution of clinical isolates of Candida spp. and antifungal susceptibility of high biofilm-forming Candida isolates

Sahal, Gulcan ; Bilkay, Isil Seyis

Revista da Sociedade Brasileira de Medicina Tropical, 2018-09, Vol.51 (5), p.644-650 [Periódico revisado por pares]

Brazil: Sociedade Brasileira de Medicina Tropical

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Título:
Distribution of clinical isolates of Candida spp. and antifungal susceptibility of high biofilm-forming Candida isolates
Autor: Sahal, Gulcan ; Bilkay, Isil Seyis
Assuntos: 5-Flucytosine ; Antifungal agents ; Antifungal Agents - pharmacology ; Antifungal resistance ; Biofilm formation ; Biofilms ; Biofilms - drug effects ; Biofilms - growth & development ; Candida ; Candida - classification ; Candida - drug effects ; Candida - physiology ; Candida albicans ; Candida Species ; Carbohydrates ; Clinical isolates ; Fermentation ; Flucytosine ; Fungi ; Fungicides ; Humans ; Identification methods ; Infections ; Itraconazole ; Microbial Sensitivity Tests ; Non-Candida albicans ; Species ; TROPICAL MEDICINE ; Urine ; Vagina ; Voriconazole
É parte de: Revista da Sociedade Brasileira de Medicina Tropical, 2018-09, Vol.51 (5), p.644-650
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The increase in the incidence of fungal infections, especially those caused by Candida albicans and other Candida species, necessitates the understanding and treatment of Candida-associated infections. In this study, we aimed to investigate the identification, distribution, and biofilm formation ability of different clinical Candida isolates and evaluate the distribution and antifungal susceptibilities of high biofilm-forming (HBF) Candida isolates. For identification, carbohydrate fermentation, carbohydrate assimilation, and ChromAgar tests were used. Biofilm formation was assessed using crystal violet binding assay, while the susceptibility to antifungal agents was determined using ATBTM Fungus 3 test kits. The majority of Candida species were C. parapsilosis (31.3%; 31/99) and C. tropicalis (30.3%; 30/99). C. tropicalis was found to be the most frequently isolated species among all HBF Candida species. HBF Candida isolates were more frequently isolated from vaginal swab (35.7%; 10/28), tracheal aspirate (17.9%; 5/28), and urine (17.9%; 5/28). The majority of tested isolates were resistant to itraconazole and voriconazole, whereas no isolate was deemed resistant to 5-flucytosine. C. tropicalis displays the highest biofilm formation ability among all the Candida species evaluated, and HBF Candida isolates were more frequently seen in vaginal swab, tracheal aspirate, and urine samples. Our findings revealed that 5-flucytosine is the most efficient antifungal agent against HBF Candida isolates.
Editor: Brazil: Sociedade Brasileira de Medicina Tropical
Idioma: Inglês;Português

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Distribution of clinical isolates of Candida spp. and antifungal susceptibility of high biofilm-forming Candida isolates

Sahal, Gulcan ; Bilkay, Isil Seyis

Brazil: Sociedade Brasileira de Medicina Tropical

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