Idioma:

A prospective study of the clinical outcomes and prognosis associated with comorbid COPD in the atrial fibrillation population

Rodríguez-Mañero, Moisés ; López-Pardo, Estrella ; Cordero, Alberto ; Ruano-Ravina, Alberto ; Novo-Platas, José ; Pereira-Vázquez, María ; Martínez-Gómez, Álvaro ; García-Seara, Javier ; Martínez-Sande, Jose-Luis ; Peña-Gil, Carlos ; Mazón, Pilar ; García-Acuña, Jose María ; Valdés-Cuadrado, Luis ; González-Juanatey, José Ramón

International journal of chronic obstructive pulmonary disease, 2019-01, Vol.14, p.371-380 [Periódico revisado por pares]

New Zealand: Dove Medical Press Limited

Texto completo disponível

Citações Citado por

Enviar para

Título:
A prospective study of the clinical outcomes and prognosis associated with comorbid COPD in the atrial fibrillation population
Autor: Rodríguez-Mañero, Moisés ; López-Pardo, Estrella ; Cordero, Alberto ; Ruano-Ravina, Alberto ; Novo-Platas, José ; Pereira-Vázquez, María ; Martínez-Gómez, Álvaro ; García-Seara, Javier ; Martínez-Sande, Jose-Luis ; Peña-Gil, Carlos ; Mazón, Pilar ; García-Acuña, Jose María ; Valdés-Cuadrado, Luis ; González-Juanatey, José Ramón
Assuntos: Action Potentials ; Adolescent ; Adrenergic Antagonists - therapeutic use ; Adult ; Age ; Aged ; Aged, 80 and over ; Anti-Arrhythmia Agents - therapeutic use ; Anticoagulants - therapeutic use ; Atrial fibrillation ; Atrial Fibrillation - drug therapy ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - mortality ; Atrial Fibrillation - physiopathology ; Beta blockers ; big data ; Bronchodilator Agents - therapeutic use ; Cardiac arrhythmia ; Cardiac patients ; Cause of Death ; CHA2DS2-VASc ; Child ; Child, Preschool ; Chronic obstructive pulmonary disease ; Clinical outcomes ; Comorbidity ; COPD ; Data Warehousing ; Diabetes ; Digoxin ; Digoxin - therapeutic use ; Embolisms ; Enzymes ; Female ; Health care industry ; Heart attacks ; Heart Conduction System - physiopathology ; Heart failure ; Heart Rate ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Information systems ; Lung - physiopathology ; Male ; Middle Aged ; Mortality ; Original Research ; Patient outcomes ; Patients ; Population ; Prognosis ; Prospective Studies ; Protective Factors ; Pulmonary Disease, Chronic Obstructive - drug therapy ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Pulmonary Disease, Chronic Obstructive - mortality ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Regression analysis ; Risk Assessment ; Risk Factors ; Spain ; Spain - epidemiology ; stroke ; Thromboembolism ; Time Factors ; Treatment Outcome ; Young Adult
É parte de: International journal of chronic obstructive pulmonary disease, 2019-01, Vol.14, p.371-380
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work
Descrição: Patients with COPD are at higher risk of presenting with atrial fibrillation (AF). Information about clinical outcomes and optimal medical treatment of AF in the setting of COPD remains missing. We aimed to describe the prevalence of COPD in a sizeable cohort of real-world AF patients belonging to the same healthcare area and to examine the relationship between comorbid COPD and AF prognosis. Prospective analysis performed in a specific healthcare area. Data were obtained from several sources within the "data warehouse of the Galician Healthcare Service" using multiple analytical tools. Statistical analyses were completed using SPSS 19 and STATA 14.0. A total of 7,990 (2.08%) patients with AF were registered throughout 2013 in our healthcare area (n=348,985). Mean age was 76.83±10.51 years and 937 (11.7%) presented with COPD. COPD patients had a higher mean CHA DS -VASc (4.21 vs 3.46; =0.02) and received less beta-blocker and more digoxin therapy than those without COPD. During a mean follow-up of 707±103 days, 1,361 patients (17%) died. All-cause mortality was close to two fold higher in the COPD group (28.3% vs 15.5%; <0.001). Independent predictive factors for all-cause mortality were age, heart failure, diabetes, previous thromboembolic event, dementia, COPD, and oral anticoagulation (OA). There were nonsignificant differences in thromboembolic events (1.7% vs 1.5%; =0.7), but the rate of hemorrhagic events was significantly higher in the COPD group (3.3% vs 1.9%; =0.004). Age, valvular AF, OA, and COPD were independent predictive factors for hemorrhagic events. In COPD patients, age, heart failure, vasculopathy, lack of OA, and lack of beta-blocker use were independent predictive factors for all-cause mortality. AF patients with COPD have a higher incidence of adverse events with significantly increased rates of all-cause mortality and hemorrhagic events than AF patients without COPD. However, comorbid COPD was not associated with differences in cardiovascular death or stroke rate. OA and beta-blocker treatment presented a risk reduction in mortality while digoxin use exerted a neutral effect.
Editor: New Zealand: Dove Medical Press Limited
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

A prospective study of the clinical outcomes and prognosis associated with comorbid COPD in the atrial fibrillation population

New Zealand: Dove Medical Press Limited

Buscando em bases de dados remotas. Favor aguardar.