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Chemical Constituents from Roots of Sophora davidii (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities

Li, Kangdi ; Ma, Yuanren ; Zhou, Tongxi ; Yang, Xinzhou ; Choi, Ho-Young

Molecules (Basel, Switzerland), 2021-02, Vol.26 (3), p.756 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Chemical Constituents from Roots of Sophora davidii (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities
Autor: Li, Kangdi ; Ma, Yuanren ; Zhou, Tongxi ; Yang, Xinzhou ; Choi, Ho-Young
Assuntos: Absolute configuration ; Acetic acid ; Aromatic compounds ; arylbenzofuran ; Carbon ; Circular dichroism ; Cotton ; Diabetes ; Diabetes mellitus ; Dichroism ; Drug development ; ECD ; Ethyl acetate ; Glucose ; Glucose transporter ; Glucose Transporter Type 4 - metabolism ; GLUT-4 ; Insulin resistance ; isoflavan ; Mass spectroscopy ; Medical treatment ; Metabolism ; Molecular Structure ; NMR ; Nuclear magnetic resonance ; Pharmaceutical industry ; Plant Roots - chemistry ; Protein Transport ; R&D ; Research & development ; Sophora - chemistry ; Sophora davidii ; Sophora davidii (Franch.) Skeels ; Stilbene ; stilbene oligomers ; Stilbenes - analysis ; Stilbenes - chemistry ; Stilbenes - isolation & purification ; Stilbenes - pharmacology ; Translocation
É parte de: Molecules (Basel, Switzerland), 2021-02, Vol.26 (3), p.756
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors contributed equally to this work.
Descrição: (Franch.) Skeels is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of , a chemical investigation was thus performed. In this research, two new stilbene oligomers, Davidiol E-F ( - ), one new 4-aryl-substituted isoflavan Davidinin A ( ), and one new 2-arylbenzofuran dimer, Shandougenine C ( ), as well as six known compounds ( - ) were obtained from the ethyl acetate fraction of (Franch.) Skeels. The structures of new compounds were established by extensive 1D and 2D nuclear magnetic resonance (NMR) spectra with mass spectroscopy data. The absolute configuration of - was assigned by comparing its experimental and calculated electronic circular dichroism (ECD) spectra. Compounds - promoted glucose transporter 4 (GLUT-4) translocations by the range of 1.28-2.60 folds, respectively. Compound showed the most potent glucose transporter 4 translocations with 1.60 fold enhancement. The result attained in this study indicated that the separation and characterization of these compounds plays an important role in the research and development of new anti-diabetic drugs and pharmaceutical industry.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Chemical Constituents from Roots of Sophora davidii (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities

Li, Kangdi ; Ma, Yuanren ; Zhou, Tongxi ; Yang, Xinzhou ; Choi, Ho-Young

Switzerland: MDPI AG

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