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The Endogenous Cannabinoid and the Nitricoxidergic Systems in the Modulation of Stress Responses

Nocheva, Hristina ; Krastev, Nikolay S ; Krastev, Dimo S ; Mileva, Milka

International journal of molecular sciences, 2023-02, Vol.24 (3), p.2886 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
The Endogenous Cannabinoid and the Nitricoxidergic Systems in the Modulation of Stress Responses
Autor: Nocheva, Hristina ; Krastev, Nikolay S ; Krastev, Dimo S ; Mileva, Milka
Assuntos: Adaptation ; Agonists ; Analgesia ; Analgesics ; Anandamide ; anandamide (AEA) ; Animals ; antinociception ; Arginine ; Cannabinoid CB1 receptors ; Cannabinoid Receptor Agonists - pharmacology ; Cannabinoids - pharmacology ; Cardiovascular disease ; Constraints ; Endocannabinoid system ; Endocannabinoids - pharmacology ; Experiments ; Homeostasis ; hot plate test ; Inhibitors ; Male ; Neurons ; Nitric oxide ; nitric oxide (NO) ; Nitric Oxide - metabolism ; Nitric-oxide synthase ; Nociception ; Pain ; Pain perception ; paw pressure test ; Physiology ; Polyunsaturated Alkamides - pharmacology ; Precursors ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1 ; restraint stress (RS) ; Stress response ; Stress, Physiological
É parte de: International journal of molecular sciences, 2023-02, Vol.24 (3), p.2886
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The effects on stress-induced analgesia (SIA) from endogenous cannabinoid system (ECS) and nitric oxide (NO) interaction after 1 h of restraint stress were evaluated in male Wistar rats. The animals were subjected to 1 h of restraint and then injected with different combinations of cannabinoid receptor type 1 agonist anandamide (AEA) or antagonist AM251 along with an NO donor, NO precursor, or inhibitor of NO synthase. Nociception was evaluated using paw pressure (PP) or hot plate (HP) tests. AEA was administered immediately after the end of restraint-SIA (r-SIA). Administration of NO precursor reversed the pronociceptive effect of the CB1 agonist on r-SIA. Both the CB1 antagonist and the NOS inhibitor neutralized the pro-analgesic effect of L-arginine (L-arg). Administration of an NO donor, instead, increased r-SIA. Our experiments confirmed that the endogenous cannabinoid and the NO-ergic systems interact in the modulation of r-SIA. This interaction probably implies NO as a second messenger of the ECS.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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The Endogenous Cannabinoid and the Nitricoxidergic Systems in the Modulation of Stress Responses

Nocheva, Hristina ; Krastev, Nikolay S ; Krastev, Dimo S ; Mileva, Milka

Switzerland: MDPI AG

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