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Non-additive microbial community responses to environmental complexity

Pacheco, Alan R ; Osborne, Melisa L ; Segrè, Daniel

Nature communications, 2021-04, Vol.12 (1), p.2365-2365, Article 2365 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Non-additive microbial community responses to environmental complexity
Autor: Pacheco, Alan R ; Osborne, Melisa L ; Segrè, Daniel
Assuntos: Bacteria - genetics ; Bacteria - metabolism ; Bacterial synthetic biology ; BASIC BIOLOGICAL SCIENCES ; Biodiversity ; Bioengineering - methods ; Carbon - metabolism ; Cell Culture Techniques - methods ; community ecology ; Complexity ; Consortia ; Culture Media - metabolism ; Environmental changes ; Epistasis ; Metabolism ; Metabolomics ; Microbial Consortia - physiology ; microbial ecology ; microbiome ; Microbiomes ; Microorganisms ; Models, Biological ; Nutrients - metabolism ; Taxonomy
É parte de: Nature communications, 2021-04, Vol.12 (1), p.2365-2365, Article 2365
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
AC02-05CH11231; R01DE024468; R01GM121950; UH2AG064704; 1457695; 1635070
National Science Foundation (NSF)
National Institutes of Health (NIH)
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Descrição: Environmental composition is a major, though poorly understood, determinant of microbiome dynamics. Here we ask whether general principles govern how microbial community growth yield and diversity scale with an increasing number of environmental molecules. By assembling hundreds of synthetic consortia in vitro, we find that growth yield can remain constant or increase in a non-additive manner with environmental complexity. Conversely, taxonomic diversity is often much lower than expected. To better understand these deviations, we formulate metrics for epistatic interactions between environments and use them to compare our results to communities simulated with experimentally-parametrized consumer resource models. We find that key metabolic and ecological factors, including species similarity, degree of specialization, and metabolic interactions, modulate the observed non-additivity and govern the response of communities to combinations of resource pools. Our results demonstrate that environmental complexity alone is not sufficient for maintaining community diversity, and provide practical guidance for designing and controlling microbial ecosystems.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Non-additive microbial community responses to environmental complexity

Pacheco, Alan R ; Osborne, Melisa L ; Segrè, Daniel

England: Nature Publishing Group

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