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Association between smoking, crack cocaine abuse and the discontinuation of combination antiretroviral therapy in Recife, Pernambuco, Brazil

Batista, Joanna d'Arc Lyra ; Albuquerque, Maria de Fátima Pessoa Militão de ; Santos, Marcela Lopes ; Miranda-Filho, Demócrito de Barros ; Lacerda, Heloísa Ramos ; Maruza, Magda ; Moura, Libia Vilela ; Coimbra, Isabella ; Ximenes, Ricardo Arraes de Alencar

Revista do Instituto de Medicina Tropical de São Paulo, 2014-03, Vol.56 (2), p.127-132 [Periódico revisado por pares]

Brazil: Instituto de Medicina Tropical de Sao Paulo

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Título:
Association between smoking, crack cocaine abuse and the discontinuation of combination antiretroviral therapy in Recife, Pernambuco, Brazil
Autor: Batista, Joanna d'Arc Lyra ; Albuquerque, Maria de Fátima Pessoa Militão de ; Santos, Marcela Lopes ; Miranda-Filho, Demócrito de Barros ; Lacerda, Heloísa Ramos ; Maruza, Magda ; Moura, Libia Vilela ; Coimbra, Isabella ; Ximenes, Ricardo Arraes de Alencar
Assuntos: Adherence ; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; AIDS ; Anti-HIV Agents - therapeutic use ; Antiretroviral therapy ; Associated factors ; Cocaine-Related Disorders - complications ; Crack Cocaine ; Cross-Sectional Studies ; Female ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV/AIDS ; Humans ; Male ; Medication Adherence - statistics & numerical data ; Middle Aged ; Smoking - adverse effects ; Socioeconomic Factors ; TROPICAL MEDICINE ; Young Adult
É parte de: Revista do Instituto de Medicina Tropical de São Paulo, 2014-03, Vol.56 (2), p.127-132
Notas: Competing Interests: The authors declared that there are no competing interests.
Descrição: Despite the effectiveness of combination antiretroviral therapy in the treatment of people living with HIV/AIDS (PLWHA), nonadherence to medication has become a major threat to its effectiveness. This study aimed to estimate the prevalence of self-reported irregular use of antiretroviral therapy and the factors associated with such an irregularity in PLWHA. A cross-sectional study of PLWHA who attended two referral centers in the city of Recife, in Northeastern Brazil, between June 2007 and October 2009 was carried out. The study analyzed socioeconomic factors, social service support and personal habits associated with nonadherence to antiretroviral therapy, adjusted by multivariable logistic regression analysis. The prevalence of PLWHA who reported irregular use of combination antiretroviral therapy (cART) was 25.7%. In the final multivariate model, the irregular use of cART was associated with the following variables: being aged less than 40 years (OR = 1.66, 95%-CI: 1.29-2.13), current smokers (OR = 1.76, 95%-CI: 1.31-2.37) or former smokers (OR = 1.43, 95%-CI: 1.05-1.95), and crack cocaine users (OR = 2.79, 95%-CI: 1.24-6.32). Special measures should be directed towards each of the following groups: individuals aged less than 40 years, smokers, former smokers and crack cocaine users. Measures for giving up smoking and crack cocaine should be incorporated into HIV-control programs in order to promote greater adherence to antiretroviral drugs and thus improve the quality of life and prolong life expectancy.
Editor: Brazil: Instituto de Medicina Tropical de Sao Paulo
Idioma: Inglês;Português

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Association between smoking, crack cocaine abuse and the discontinuation of combination antiretroviral therapy in Recife, Pernambuco, Brazil

Batista, Joanna d'Arc Lyra ; Albuquerque, Maria de Fátima Pessoa Militão de ; Santos, Marcela Lopes ; Miranda-Filho, Demócrito de Barros ; Lacerda, Heloísa Ramos ; Maruza, Magda ; Moura, Libia Vilela ; Coimbra, Isabella ; Ximenes, Ricardo Arraes de Alencar

Brazil: Instituto de Medicina Tropical de Sao Paulo

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