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Iron deposition in Parkinson's disease by quantitative susceptibility mapping

Chen, Qiqi ; Chen, Yiting ; Zhang, Yue ; Wang, Furu ; Yu, Hongchang ; Zhang, Caiyuan ; Jiang, Zhen ; Luo, Weifeng

BMC neuroscience, 2019-05, Vol.20 (1), p.23-23, Article 23 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Iron deposition in Parkinson's disease by quantitative susceptibility mapping
Autor: Chen, Qiqi ; Chen, Yiting ; Zhang, Yue ; Wang, Furu ; Yu, Hongchang ; Zhang, Caiyuan ; Jiang, Zhen ; Luo, Weifeng
Assuntos: Age ; Analysis ; Brain Mapping - methods ; Case-Control Studies ; Caudate nucleus ; Diagnosis ; Diagnostic imaging ; Disease ; Disease susceptibility ; Dopamine ; Dopamine receptors ; Female ; Globus pallidus ; Globus Pallidus - metabolism ; Gray Matter - metabolism ; Humans ; Iron ; Iron (Nutrient) ; Iron - metabolism ; Iron deposition ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Movement disorders ; Neural Pathways - metabolism ; Neurodegenerative diseases ; Neuroimaging ; Parkinson disease ; Parkinson Disease - metabolism ; Parkinson's disease ; Putamen ; Quantitative susceptibility mapping ; Red nucleus ; Severity of Illness Index ; Studies ; Substantia grisea ; Substantia nigra ; Substantia Nigra - metabolism ; Substantia nigra pars reticulata
É parte de: BMC neuroscience, 2019-05, Vol.20 (1), p.23-23, Article 23
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Patients with Parkinson's disease (PD) have elevated levels of brain iron, especially in the nigrostriatal dopaminergic system. The purpose of this study was to evaluate the iron deposition in the substantia nigra (SN) and other deep gray matter nuclei of PD patients using quantitative susceptibility mapping (QSM) and its clinical relationship, and to explore whether there is a gradient of iron deposition pattern in globus pallidus (GP)-fascicula nigrale (FN)-SN pathway. Thirty-three PD patients and 26 age- and sex-matched healthy volunteers (HVs) were included in this study. Subjects underwent brain MRI and constructed QSM data. The differences in iron accumulation in the deep gray matter nuclei of the subjects were compared, including the PD group and the control group, the early-stage PD (EPD) group and the late-stage PD (LPD) group. The iron deposition pattern of the GP-FN-SN pathway was analyzed. The PD group showed increased susceptibility values in the FN, substantia nigra pars compacta (SNc), internal globus pallidus (GPi), red nucleus (RN), putamen and caudate nucleus compared with the HV group (P < 0.05). In both PD and HV group, iron deposition along the GP-FN-SN pathway did not show an increasing gradient pattern. The SNc, substantia nigra pars reticulata (SNr) and RN showed significantly increased susceptibility values in the LPD patients compared with the EPD patients. PD is closely related to iron deposition in the SNc. The condition of PD patients is related to the SNc and the SNr. There is not an increasing iron deposition gradient along the GP-FN-SN pathway. The source and mechanism of iron deposition in the SN need to be further explored, as does the relationship between the iron deposition in the RN and PD.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Iron deposition in Parkinson's disease by quantitative susceptibility mapping

Chen, Qiqi ; Chen, Yiting ; Zhang, Yue ; Wang, Furu ; Yu, Hongchang ; Zhang, Caiyuan ; Jiang, Zhen ; Luo, Weifeng

England: BioMed Central Ltd

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