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Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

Zhang, Xu ; Shi, Hui ; Yuan, Xiao ; Jiang, Pengcheng ; Qian, Hui ; Xu, Wenrong

Molecular cancer, 2018-10, Vol.17 (1), p.146-146, Article 146 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration
Autor: Zhang, Xu ; Shi, Hui ; Yuan, Xiao ; Jiang, Pengcheng ; Qian, Hui ; Xu, Wenrong
Assuntos: Activation ; Angiogenesis ; Autophagy ; Autophagy - drug effects ; Breast cancer ; Cancer cells ; Cell activation ; Cell adhesion & migration ; Cell interactions ; Cell Line, Tumor ; Cell Movement - drug effects ; Cell Polarity ; Cell survival ; Culture Media, Conditioned - pharmacology ; Development and progression ; Exosome ; Exosomes ; Exosomes - metabolism ; Gastric cancer ; Gene expression ; Gene Knockdown Techniques ; Genetic aspects ; Genotype & phenotype ; HMGB1 protein ; HMGB1 Protein - metabolism ; Humans ; Inflammation ; Leukocyte migration ; Leukocytes (neutrophilic) ; Ligands ; Lymphocytes ; Macrophages - immunology ; Macrophages - metabolism ; Medical prognosis ; Metastasis ; Models, Biological ; Neutrophil ; Neutrophil Activation - genetics ; Neutrophil Activation - immunology ; Neutrophils ; Neutrophils - immunology ; Neutrophils - metabolism ; NF-kappa B ; NF-κB protein ; Phagocytosis ; Phenotypes ; Pro-tumor ; Protein Binding ; Regulation ; Signal Transduction - drug effects ; Stem cells ; Stomach cancer ; Stomach Neoplasms - genetics ; Stomach Neoplasms - immunology ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Systematic review ; TLR4 protein ; Toll-Like Receptor 4 - metabolism ; Toll-like receptors ; Tumor cell lines ; Vascular endothelial growth factor
É parte de: Molecular cancer, 2018-10, Vol.17 (1), p.146-146, Article 146
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Exosomes are extracellular vesicles that mediate cellular communication in health and diseases. Neutrophils could be polarized to a pro-tumor phenotype by tumor. The function of tumor-derived exosomes in neutrophil regulation remains unclear. We investigated the effects of gastric cancer cell-derived exosomes (GC-Ex) on the pro-tumor activation of neutrophils and elucidated the underlying mechanisms. GC-Ex prolonged neutrophil survival and induced expression of inflammatory factors in neutrophils. GC-Ex-activated neutrophils, in turn, promoted gastric cancer cell migration. GC-Ex transported high mobility group box-1 (HMGB1) that activated NF-κB pathway through interaction with TLR4, resulting in an increased autophagic response in neutrophils. Blocking HMGB1/TLR4 interaction, NF-κB pathway, and autophagy reversed GC-Ex-induced neutrophil activation. Silencing HMGB1 in gastric cancer cells confirmed HMGB1 as a key factor for GC-Ex-mediated neutrophil activation. Furthermore, HMGB1 expression was upregulated in gastric cancer tissues. Increased HMGB1 expression was associated with poor prognosis in patients with gastric cancer. Finally, gastric cancer tissue-derived exosomes acted similarly as exosomes derived from gastric cancer cell lines in neutrophil activation. We demonstrate that gastric cancer cell-derived exosomes induce autophagy and pro-tumor activation of neutrophils via HMGB1/TLR4/NF-κB signaling, which provides new insights into mechanisms for neutrophil regulation in cancer and sheds lights on the multifaceted role of exosomes in reshaping tumor microenvironment.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

Zhang, Xu ; Shi, Hui ; Yuan, Xiao ; Jiang, Pengcheng ; Qian, Hui ; Xu, Wenrong

England: BioMed Central Ltd

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