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Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

Colpitts, Che C ; Tsai, Pei-Ling ; Zeisel, Mirjam B

International journal of molecular sciences, 2020-03, Vol.21 (6), p.2091 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
Autor: Colpitts, Che C ; Tsai, Pei-Ling ; Zeisel, Mirjam B
Assuntos: Binding sites ; cell-to-cell transmission ; Chronic infection ; endocytosis ; fusion ; Genomes ; Glycoproteins ; Heparan sulfate ; Hepatitis ; Hepatitis C ; hepatitis c virus ; hepatocyte ; Hepatocytes ; Human health and pathology ; Hépatology and Gastroenterology ; Infections ; Life Sciences ; Lipids ; Lipoproteins ; Liver ; Liver diseases ; Medical research ; Microbiology and Parasitology ; Microscopy ; Molecular modelling ; Proteins ; Researchers ; Review ; Tropism ; Vaccines ; viral entry ; Viral infections ; Virology ; Viruses
É parte de: International journal of molecular sciences, 2020-03, Vol.21 (6), p.2091
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
PMCID: PMC7140000
Descrição: Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

Colpitts, Che C ; Tsai, Pei-Ling ; Zeisel, Mirjam B

Switzerland: MDPI AG

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