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The association of allergic asthma and carotid intima-media thickness in adolescence: data of the prospective early vascular ageing (EVA)-Tyrol cohort study

Winder, Bernhard ; Kiechl, Sophia J ; Gruber, Nadja M ; Bernar, Benoît ; Gande, Nina ; Staudt, Anna ; Stock, Katharina ; Hochmayr, Christoph ; Geiger, Ralf ; Griesmacher, Andrea ; Anliker, Markus ; Kiechl, Stefan ; Kiechl-Kohlendorfer, Ursula ; Knoflach, Michael

BMC cardiovascular disorders, 2022-01, Vol.22 (1), p.11-11, Article 11 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
The association of allergic asthma and carotid intima-media thickness in adolescence: data of the prospective early vascular ageing (EVA)-Tyrol cohort study
Autor: Winder, Bernhard ; Kiechl, Sophia J ; Gruber, Nadja M ; Bernar, Benoît ; Gande, Nina ; Staudt, Anna ; Stock, Katharina ; Hochmayr, Christoph ; Geiger, Ralf ; Griesmacher, Andrea ; Anliker, Markus ; Kiechl, Stefan ; Kiechl-Kohlendorfer, Ursula ; Knoflach, Michael
Assuntos: Adolescent ; Adolescents ; Age ; Aging ; Aging - physiology ; Allergic asthma ; Allergies ; Arteriosclerosis ; Asthma ; Asthma - complications ; Asthma - diagnosis ; Asthma - epidemiology ; Atherosclerosis ; Blood pressure ; Cardiovascular diseases ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Care and treatment ; Carotid Arteries - diagnostic imaging ; Carotid Intima-Media Thickness ; Child ; Children ; Cholesterol ; Clinical studies ; Cohort analysis ; Complications and side effects ; Diagnosis ; Female ; Females ; Health aspects ; Humans ; Incidence ; Laboratories ; Male ; Medical care ; Patient outcomes ; Pediatrics ; Prevention ; Prospective Studies ; Quality management ; Regression analysis ; Risk Factors ; Standard deviation ; Statistical analysis ; Survival Rate - trends ; Teenagers ; Ultrasonic imaging ; Variables
É parte de: BMC cardiovascular disorders, 2022-01, Vol.22 (1), p.11-11, Article 11
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: In recent years, there has been increasing evidence that asthma is associated with atherosclerosis and cardiovascular disease. However, data in children and adolescents are scarce and conflicting. We aimed to assess the impact of asthma with and without an allergic component on the carotid intima-media thickness in a large pediatric population. The community-based early vascular ageing-Tyrol cohort study was performed between May 2015 and July 2018 in North, East (Austria) and South Tyrol (Italy) and recruited youngster aged 14 years and above. Medical examinations included anthropometric measurements, fasting blood analysis, measurement of the carotid intima-media thickness by high-resolution ultrasound, and a physician guided interview. The mean age of the 1506 participants was 17.8 years (standard deviation 0.90). 851 (56.5%) participants were female. 22 subjects had a physician diagnosis of non-allergic asthma, 268 had inhalative allergies confirmed by a positive radio-allergo-sorbent-test and/or prick test, and 58 had allergic asthma. Compared to healthy controls, participants with non-allergic asthma (411.7 vs. 411.7 µm; p = 0.932) or inhalative allergy (420.0 vs. 411.7 µm; p = 0.118) did not have significantly higher carotid intima-media thickness (cIMT). However, participants with allergic asthma had significantly higher cIMT (430.8 vs. 411.7; p = 0.004) compared to those without and this association remained significant after multivariable adjustment for established cardiovascular risk factors. Allergic asthma in the youth is associated with an increased carotid intima-media thickness. Physicians should therefore be aware of allergic asthma as a potential cardiovascular risk factor in children and adolescents. Trial Registration Number The EVA-Tyrol Study has been retrospectively registered at clinicaltrials.gov under NCT03929692 since April 29, 2019.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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The association of allergic asthma and carotid intima-media thickness in adolescence: data of the prospective early vascular ageing (EVA)-Tyrol cohort study

Winder, Bernhard ; Kiechl, Sophia J ; Gruber, Nadja M ; Bernar, Benoît ; Gande, Nina ; Staudt, Anna ; Stock, Katharina ; Hochmayr, Christoph ; Geiger, Ralf ; Griesmacher, Andrea ; Anliker, Markus ; Kiechl, Stefan ; Kiechl-Kohlendorfer, Ursula ; Knoflach, Michael

England: BioMed Central Ltd

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