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The Vasorelaxant Effect of p-Cymene in Rat Aorta Involves Potassium Channels

Silva, Martapolyana T. M. ; Ribeiro, Fernanda P. R. A. ; Medeiros, Maria Alice M. B. ; Sampaio, Pedrita A. ; Silva, Yonara M. S. ; Silva, Morganna T. A. ; Quintans, Jullyana S. S. ; Quintans-Júnior, Lucindo J. ; Ribeiro, Luciano A. A. Norel, Xavier

TheScientificWorld, 2015-01, Vol.2015, p.458080-6 [Periódico revisado por pares]

United States: Hindawi Publishing Corporation

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Título:
The Vasorelaxant Effect of p-Cymene in Rat Aorta Involves Potassium Channels
Autor: Silva, Martapolyana T. M. ; Ribeiro, Fernanda P. R. A. ; Medeiros, Maria Alice M. B. ; Sampaio, Pedrita A. ; Silva, Yonara M. S. ; Silva, Morganna T. A. ; Quintans, Jullyana S. S. ; Quintans-Júnior, Lucindo J. ; Ribeiro, Luciano A. A.
Norel, Xavier
Assuntos: 4-Aminopyridine - pharmacology ; Animals ; Aorta - drug effects ; Aromatic plants ; Cesium - pharmacology ; Chlorides - pharmacology ; Dimethyl Sulfoxide - pharmacology ; Endothelium ; Glyburide - pharmacology ; Health aspects ; Laboratory animals ; Male ; Monoterpenes ; Monoterpenes - pharmacology ; Muscle, Smooth, Vascular - drug effects ; Phenylephrine - pharmacology ; Potassium ; Potassium Channel Blockers - pharmacology ; Potassium channels ; Potassium Channels - drug effects ; Potassium Channels - physiology ; Rats ; Rats, Wistar ; Rodents ; Smooth muscle ; Tetraethylammonium - pharmacology ; Vasodilation - drug effects ; Vasodilator Agents - pharmacology
É parte de: TheScientificWorld, 2015-01, Vol.2015, p.458080-6
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Xavier Norel
Descrição: The monoterpenes are the main constituents of most essential oils and p-cymene is a monoterpene commonly found in various species of aromatic herbs, which has been reported for anti-inflammatory, antinociceptive, and antimicrobial activities. However, there is no report concerning its pharmacological activity on the vascular smooth muscle. The aim of current work was to investigate the effects of p-cymene in isolated rat aorta and also study its mechanism of action. In this work, we show that p-cymene has a relaxant effect, in a dose-dependent way, on the vascular smooth muscle, regardless of the presence of the endothelium. Using a nonselective potassium channel blocker, the CsCl, the relaxant effect of p-cymene was attenuated. In the presence of more selective potassium channels blockers, such as TEA or 4-AP, no change in the relaxant effect of p-cymene was evidenced, indicating that BK Ca and K V channels are not involved in that relaxant effect. However, in the presence of glibenclamide or BaCl2, K ATP and K ir blockers, respectively, the relaxant effect of p-cymene was attenuated. The data presented indicate that p-cymene has a relaxing effect on rat aorta, regardless of the endothelium, but with the participation of the K ATP and K ir channels.
Editor: United States: Hindawi Publishing Corporation
Idioma: Inglês

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The Vasorelaxant Effect of p-Cymene in Rat Aorta Involves Potassium Channels

Silva, Martapolyana T. M. ; Ribeiro, Fernanda P. R. A. ; Medeiros, Maria Alice M. B. ; Sampaio, Pedrita A. ; Silva, Yonara M. S. ; Silva, Morganna T. A. ; Quintans, Jullyana S. S. ; Quintans-Júnior, Lucindo J. ; Ribeiro, Luciano A. A. Norel, Xavier

United States: Hindawi Publishing Corporation

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