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NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

Santos, Ariana C F ; Monteiro, Luís P G ; Gomes, Adriana C C ; Martel, Fátima ; Santos, Teresa M ; Ferreira, Bárbara J M Leite

International journal of molecular sciences, 2022-03, Vol.23 (5), p.2855 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments
Autor: Santos, Ariana C F ; Monteiro, Luís P G ; Gomes, Adriana C C ; Martel, Fátima ; Santos, Teresa M ; Ferreira, Bárbara J M Leite
Assuntos: Anti-inflammatory agents ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; anti-tumor activity ; Antiinfectives and antibacterials ; antimicrobial properties ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; antioxidant activity ; Antioxidants ; Biological activity ; Biomedical materials ; Cancer ; Cell division ; Cisplatin ; Cobalt ; Cobalt compounds ; Coordination Complexes - chemistry ; Coordination Complexes - pharmacology ; Coordination Complexes - therapeutic use ; Copper - chemistry ; Drug resistance ; Drugs ; Enzymes ; Fever ; first-row transition metals ; Inflammation ; interaction with biomolecules ; Ligands ; Manganese ; Metabolism ; Metal compounds ; Metal ions ; Metals ; Metals - chemistry ; Nonsteroidal anti-inflammatory drugs ; NSAID-based coordination compounds ; Respiration ; Review ; Transition metal compounds ; Transition metals ; Zinc
É parte de: International journal of molecular sciences, 2022-03, Vol.23 (5), p.2855
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic effects, an incredible amount of research in the area of coordination chemistry has been produced. Other transition metal compounds were studied, and several new relevant metallodrugs have been synthetized in the past few years. This review is focused on coordination compounds with first-row transition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or effective pharmacological properties. It is known that metal complexes, once bound to organic drugs, can enhance the drugs' biological activities, such as anticancer, antimicrobial or anti-inflammatory ones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever. NSAIDs' properties can be strongly improved when included in complexes using their compositional N and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the research on this topic and on the promising or effective results that complexes of first-row transition metals and NSAIDs can exhibit.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

Santos, Ariana C F ; Monteiro, Luís P G ; Gomes, Adriana C C ; Martel, Fátima ; Santos, Teresa M ; Ferreira, Bárbara J M Leite

Switzerland: MDPI AG

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