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The anticancer properties of iron core-gold shell nanoparticles in colorectal cancer cells

Wu, Ya-Na ; Wu, Ping-Ching ; Yang, Li-Xing ; Ratinac, Kyle R ; Thordarson, Pall ; Jahn, Kristina A ; Chen, Dong-Hwang ; Shieh, Dar-Bin ; Braet, Filip

International journal of nanomedicine, 2013-01, Vol.8 (1), p.3321-3331 [Revista revisada por pares]

New Zealand: Dove Medical Press Limited

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Título:
The anticancer properties of iron core-gold shell nanoparticles in colorectal cancer cells
Autor: Wu, Ya-Na ; Wu, Ping-Ching ; Yang, Li-Xing ; Ratinac, Kyle R ; Thordarson, Pall ; Jahn, Kristina A ; Chen, Dong-Hwang ; Shieh, Dar-Bin ; Braet, Filip
Materias: Apoptosis - drug effects ; Caco-2 Cells ; Cancer ; cancer therapy ; Care and treatment ; Cell Line, Tumor ; Cell Survival - drug effects ; Colorectal cancer ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - pathology ; Cytotoxicity ; differential cytotoxicity ; Gold - therapeutic use ; Gold compounds ; gold-coated iron ; HT29 Cells ; Humans ; Iron - therapeutic use ; Iron compounds ; Metal Nanoparticles - therapeutic use ; Metal Nanoparticles - ultrastructure ; Nanoparticles ; Oncology, Experimental ; Oral cancer ; Original Research ; Particle Size ; Properties
Es parte de: International journal of nanomedicine, 2013-01, Vol.8 (1), p.3321-3331
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descripción: Previously, iron core-gold shell nanoparticles (Fe@Au) have been shown to possess cancer-preferential cytotoxicity in oral and colorectal cancer (CRC) cells. However, CRC cell lines are less sensitive to Fe@Au treatment when compared with oral cancer cell lines. In this research, Fe@Au are found to decrease the cell viability of CRC cell lines, including Caco-2, HT-29, and SW480, through growth inhibition rather than the induction of cell death. The cytotoxicity induced by Fe@Au in CRC cells uses different subcellular pathways to the mitochondria-mediated autophagy found in Fe@Au-treated oral cancer cells, OECM1. Interestingly, the Caco-2 cell line shows a similar response to OECM1 cells and is thus more sensitive to Fe@Au treatment than the other CRC cell lines studied. We have investigated the underlying cell resistance mechanisms of Fe@Au-treated CRC cells. The resistance of CRC cells to Fe@Au does not result from the total amount of Fe@Au internalized. Instead, the different amounts of Fe and Au internalized appear to determine the different response to treatment with Fe-only nanoparticles in Fe@Au-resistant CRC cells compared with the Fe@Au-sensitive OECM1 cells. The only moderately cytotoxic effect of Fe@Au nanoparticles on CRC cells, when compared to the highly sensitive OECM1 cells, appears to arise from the CRC cells' relative insensitivity to Fe, as is demonstrated by our Fe-only treatments. This is a surprising outcome, given that Fe has thus far been considered to be the "active" component of Fe@Au nanoparticles. Instead, we have found that the Au coatings, previously considered only as a passivating coating to protect the Fe cores from oxidation, significantly enhance the cytotoxicity of Fe@Au in certain CRC cells. Therefore, we conclude that both the Fe and Au in these core-shell nanoparticles are essential for the anticancer properties observed in CRC cells.
Editor: New Zealand: Dove Medical Press Limited
Idioma: Inglés

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The anticancer properties of iron core-gold shell nanoparticles in colorectal cancer cells

Wu, Ya-Na ; Wu, Ping-Ching ; Yang, Li-Xing ; Ratinac, Kyle R ; Thordarson, Pall ; Jahn, Kristina A ; Chen, Dong-Hwang ; Shieh, Dar-Bin ; Braet, Filip

New Zealand: Dove Medical Press Limited

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