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14Ccetiofur sodium absorption, distribution, metabolism, and excretion in sheep following intramuscular injections. [English

Beconi Barker M.G ; Davison K.L ; Hornish R.E ; Arnold T.S ; Craigmill A.L ; Gilbertson T.J ; Smith E.B ; Vidmar T.J ; Hoffman G.A ; Gatchell C.L

Journal of agricultural and food chemistry, 1995, Vol.43 [Periódico revisado por pares]

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Título:
14Ccetiofur sodium absorption, distribution, metabolism, and excretion in sheep following intramuscular injections. [English
Autor: Beconi Barker M.G ; Davison K.L ; Hornish R.E ; Arnold T.S ; Craigmill A.L ; Gilbertson T.J ; Smith E.B ; Vidmar T.J ; Hoffman G.A ; Gatchell C.L
Assuntos: blood plasma ; carbon ; carbone ; carbono ; cefalosporinas ; cephalosporine ; cephalosporins ; drugs ; excrecion ; excretion ; faeces ; farmacologia ; feces ; foie ; heces ; higado ; injection ; inyeccion ; isotope radioactif ; kidneys ; liver ; medicament ; medicamentos ; metabolism ; metabolisme ; metabolismo ; metabolite ; metabolites ; metabolitos ; orina ; ovin ; ovinos ; pharmacologie ; pharmacology ; plasma sanguin ; plasma sanguineo ; radioisotopes ; radioisotopos ; rein ; residu ; residues ; residuos ; rinones ; sheep ; technique des traceurs ; tecnicas de trazadores ; tracer techniques ; urine
É parte de: Journal of agricultural and food chemistry, 1995, Vol.43
Notas: L70
L
Descrição: Six Columbia and mixed-breed sheep (three rams and three females, 33-44 kg) were euthanatized 12 h after the last of 5 intramuscular doses at 2.2 mg of [14C]ceftiofur sodium/kg of body weight. Total dose accountability was 103.5 +/- 4.5%: 92.55 +/- 4.10% in urine, 6.53 +/- 0.85% in feces, 2.40 +/- 0.14% in the carcass, and 0.69 +/- 0.32% in the intestinal tract. Kidneys were the tissues with highest residue concentration (9.016 +/- 1.153 micrograms/g, 0.29% of the dose). Most residues found in kidney and liver were associated with macromolecules (95.7% and 90.5%, respectively), of the free residues, all corresponded to polar metabolites devoid of the beta-lactam ring necessary for biological activity. Desfuroylceftiofur (DFC)-dimer was the most abundant metabolite (47.58%) found in urine. Polar metabolites devoid of a beta-lactam ring comprised 38.5% of the total residues. In plasma, DFC was conjugated to albumin. Free residues containing an intact beta-lactam ring were not found. [14C] Ceftiofur itself was never found in the exereta or plasma or as a tissue residue.
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14Ccetiofur sodium absorption, distribution, metabolism, and excretion in sheep following intramuscular injections. [English

Beconi Barker M.G ; Davison K.L ; Hornish R.E ; Arnold T.S ; Craigmill A.L ; Gilbertson T.J ; Smith E.B ; Vidmar T.J ; Hoffman G.A ; Gatchell C.L

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