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Oral and dermal application of 2,4-dichlorophenoxyacetic acid sodium and dimethylamine salts to male rats: investigations on absorption and excretion as well as induction of hepatic mixed-function oxidase activities

Knopp, D ; Schiller, F

Archives of toxicology, 1992, Vol.66 (3), p.170-174 [Periódico revisado por pares]

NEW YORK: Springer Nature

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Título:
Oral and dermal application of 2,4-dichlorophenoxyacetic acid sodium and dimethylamine salts to male rats: investigations on absorption and excretion as well as induction of hepatic mixed-function oxidase activities
Autor: Knopp, D ; Schiller, F
Assuntos: 2,4-D ; 2,4-Dichlorophenoxyacetic Acid - pharmacokinetics ; 2,4-Dichlorophenoxyacetic Acid - pharmacology ; absorption ; Administration, Cutaneous ; Administration, Oral ; Animals ; Biological and medical sciences ; cytochrome P-450 ; Cytochrome P-450 Enzyme System - biosynthesis ; Cytochrome P-450 Enzyme System - drug effects ; Dimethylamines - pharmacokinetics ; Dimethylamines - pharmacology ; enzyme activity ; Enzyme Induction ; excretion ; Herbicides - pharmacokinetics ; Herbicides - pharmacology ; Intestinal Absorption ; Life Sciences & Biomedicine ; liver ; Liver - drug effects ; Liver - enzymology ; Male ; Medical sciences ; mixed function oxidase ; Mixed Function Oxygenases - biosynthesis ; Mixed Function Oxygenases - drug effects ; oral administration ; Pesticides, fertilizers and other agrochemicals toxicology ; Rats ; Rats, Inbred Strains ; salts ; Science & Technology ; Skin Absorption ; topical application ; Toxicology ; urine
É parte de: Archives of toxicology, 1992, Vol.66 (3), p.170-174
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Absorption and urinary excretion of 2,4-dichlorophenoxyacetic acid sodium (sodium 2,4-D) and 2,4-dichlorophenoxyacetic acid dimethylammonium (2,4-DMA) salts were examined after single oral and mid-dorsal skin applications of the herbicides to male rats. Doses of 2.6 mg 2,4-D/kg body wt (sodium 2,4-D) and 1.9 mg 2,4-D/kg body wt (2,4-DMA) were applied. Quantitatively, with both salts, most of the orally administered herbicide (over 90%) was excreted in urine within 28 h. However, 2,4-D urinary peak concentrations were measured 4.5 and 20.5 h after dosing with 2,4-DMA and sodium 2,4-D, respectively. Additionally, the volume of urine in the oral study was significantly increased with both salts when compared with the controls or the dermal exposure. After topical application, 2,4-D absorption was much lower than in the oral study. Urinary excretion only reached about 10 and 15% of the applied dose for sodium 2,4-D and 2,4-DMA, respectively, by 5 days post-treatment. Further, we found some elevations in hepatic cytochrome P-450 activities. Ethylmorphine N-demethylase was only slightly induced by the herbicides while ethoxyresorufin O-deethylase activity was increased nearly 2-fold by sodium 2,4-D.
Editor: NEW YORK: Springer Nature
Idioma: Inglês

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Oral and dermal application of 2,4-dichlorophenoxyacetic acid sodium and dimethylamine salts to male rats: investigations on absorption and excretion as well as induction of hepatic mixed-function oxidase activities

Knopp, D ; Schiller, F

NEW YORK: Springer Nature

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