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Copper Complexes of Peptide Fragments of Tau Protein

Kastal, Zsuzsa ; Balabán, Adrienn ; Vida, Szilvia ; Kállay, Csilla ; Nagy, Lajos ; Várnagy, Katalin ; Sóvágó, Imre

Molecules (Basel, Switzerland), 2024-05, Vol.29 (10) [Periódico revisado por pares]

MDPI AG

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  • Título:
    Copper Complexes of Peptide Fragments of Tau Protein
  • Autor: Kastal, Zsuzsa ; Balabán, Adrienn ; Vida, Szilvia ; Kállay, Csilla ; Nagy, Lajos ; Várnagy, Katalin ; Sóvágó, Imre
  • Assuntos: Copper compounds ; Ethylenediaminetetraacetic acid ; Histidine ; Nickel ; Protein binding ; Proteins
  • É parte de: Molecules (Basel, Switzerland), 2024-05, Vol.29 (10)
  • Descrição: Copper(II), nickel(II) and zinc(II) complexes of various peptide fragments of tau protein were studied by potentiometric and spectroscopic techniques. All peptides contained one histidyl residue and represented the sequences of tau(91–97) (Ac-AQPHTEI-NH[sub.2]), tau(385–390) (Ac-KTDHGA-NH[sub.2]) and tau(404–409) (Ac-SPRHLS-NH[sub.2]). Imidazole-N donors of histidine were the primary metal binding sites for all peptides and all metal ions, but in the case of copper(II) and nickel(II), the deprotonated amide groups were also involved in metal binding by increasing pH. The most stable complexes were formed with copper(II) ions, but the presence of prolyl residues resulted in significant changes in the thermodynamic stability and speciation of the systems. It was also demonstrated that nickel(II) and especially zinc(II) complexes have relatively low thermodynamic stability with these peptides. The copper(II)-catalyzed oxidation of the peptides was also studied. In the presence of H[sub.2]O[sub.2], the fragmentation of peptides was detected in all cases. In the simultaneous presence of H[sub.2]O[sub.2] and ascorbic acid, the fragmentation of the peptide is less preferred, and the formation of 2-oxo-histidine also occurs.
  • Editor: MDPI AG
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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